Alterations of behavior and spatial learning after unilateral entorhinal ablation of rats

Zsolt Kopniczky, Roberta Dochnal, Mónika Mácsai, Ágnes Pál, Gusztáv Kiss, A. Mihály, Gyula Szabó

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The entorhinal cortex (EC) is the key input and output structure of the hippocampus. It plays a crucial role in sensory processing, memory and learning, as well as in mechanisms of epileptic seizures. Our previous studies on the 4-aminopyridin induced epilepsy model of rats showed that ablation of unilateral EC prompted weakening of limbic seizure manifestation, thus the possibility of therapeutical benefit of this kind of surgery can be risen. Open field, elevated plus-maze and Morris water-maze test were performed to analyze changes of the basal activity level, exploratory behavior, and spatial memory capacity, respectively, of adult Wistar rats having undergone left EC excision. Compared with the sham-operated control group, rats with lesions of the EC showed enhanced locomotor activity in the open-field test. The elevated plus-maze test revealed higher frequency of entries and more time spent in the open arms. Morris water-maze test suggested impairment of the spatial learning capacity following left lateral EC lesion. Therefore, our data showed that EC lesions induced hyperactivity, increased exploratory behavior, and impaired spatial learning. Entorhinal cortex ablation, as a potential method for controlling epileptic seizures has multiple effects on animals' behavior and spatial learning. To determine the cost-benefit ratio of a potential surgical intervention needs further experimental and human investigations.

Original languageEnglish
Pages (from-to)2683-2688
Number of pages6
JournalLife Sciences
Volume78
Issue number23
DOIs
Publication statusPublished - May 1 2006

Fingerprint

Entorhinal Cortex
Ablation
Rats
Data storage equipment
Water
Epilepsy
Exploratory Behavior
Surgery
Animals
Animal Behavior
Processing
Locomotion
Spatial Learning
Costs
Cost-Benefit Analysis
Wistar Rats
Hippocampus
Seizures
Learning
Control Groups

Keywords

  • Behavior
  • Entorhinal cortex
  • Epilepsy surgery
  • Hippocampus
  • Rat
  • Spatial learning

ASJC Scopus subject areas

  • Pharmacology

Cite this

Kopniczky, Z., Dochnal, R., Mácsai, M., Pál, Á., Kiss, G., Mihály, A., & Szabó, G. (2006). Alterations of behavior and spatial learning after unilateral entorhinal ablation of rats. Life Sciences, 78(23), 2683-2688. https://doi.org/10.1016/j.lfs.2005.10.014

Alterations of behavior and spatial learning after unilateral entorhinal ablation of rats. / Kopniczky, Zsolt; Dochnal, Roberta; Mácsai, Mónika; Pál, Ágnes; Kiss, Gusztáv; Mihály, A.; Szabó, Gyula.

In: Life Sciences, Vol. 78, No. 23, 01.05.2006, p. 2683-2688.

Research output: Contribution to journalArticle

Kopniczky, Z, Dochnal, R, Mácsai, M, Pál, Á, Kiss, G, Mihály, A & Szabó, G 2006, 'Alterations of behavior and spatial learning after unilateral entorhinal ablation of rats', Life Sciences, vol. 78, no. 23, pp. 2683-2688. https://doi.org/10.1016/j.lfs.2005.10.014
Kopniczky, Zsolt ; Dochnal, Roberta ; Mácsai, Mónika ; Pál, Ágnes ; Kiss, Gusztáv ; Mihály, A. ; Szabó, Gyula. / Alterations of behavior and spatial learning after unilateral entorhinal ablation of rats. In: Life Sciences. 2006 ; Vol. 78, No. 23. pp. 2683-2688.
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