Alterations in the adenylate cyclase‐cAMP‐phosphodiesterase system in the locus coeruleus during the development of spontaneous hypertension of the rat

U. Bahner, G. Schmid, H. Geiger, A. Heidland, M. Palkovits

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The quantitatively most important noradrenergic cell group of the brain is the locus coreruleus. Significantly increased cAMP concentration could be measured in spontaneously hypertensive rats in comparison to normotensive Wistar‐Kyoto control rats at every stage investigated. Furthermore, both the basal activity and maximal stimulation of Ca++‐and GTP‐dependent adenylate cyclase as well as phosphodiesterase activity were significantly decreased in the spontaneously hypertensive rats at 14 weeks of age. The possible role of the locus coeruleus in spontaneous hypertension is presumed in counterrgulatory mechanisms against rising blood pressure.

Original languageEnglish
Pages (from-to)473-478
Number of pages6
JournalJournal of Neuroscience Research
Volume18
Issue number3
DOIs
Publication statusPublished - 1987

Keywords

  • brain
  • catecholaminergic system
  • genetic hypertension
  • second messenger

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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