Alterations in the action potential ofAplysia neurons evoked by a phorbolester are mediated by protein kinase C

Andras Papp, Manfred R. Klee

Research output: Contribution to journalArticle

1 Citation (Scopus)


Alterations in the parameters of action potentials upon changes in protein kinase C (PKC) activity were studied on neurons of the visceral ganglion ofAplysia californica. The amplitude and maximum speed of the up-and downstroke of the action potentials (APs) were measured. Intracellularly injected PKC and intra-and extracellularly applied phorbol-12,13-diacetate (PDAc) had similar effects on theAplysia neurons, the most prominent being an increase of the upstroke speed of the AP in every neuron. The non-PKC-activating 4α-phorbol didecanoate had no effect, and the effects of the PKC blocker H-7 were opposite to those of PDAc. It was concluded that the changes of the AP evoked by PDAc are mediated through PKC activation.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalBrain research
Issue number1
Publication statusPublished - Jun 26 1995



  • Action potential
  • Aplysia
  • H-7
  • Phorbol diacetate
  • Protein kinase C

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this