Alterations in stomach wall glycoproteins during gastric ulceration induced by pyloric ligation

Gy Müzsik, T. Karsai, F. Teichmann

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Alterations of glycoproteins prepared from the glandular (pyloric) and membranous (rumenal) parts of the stomach wall of rats have been studied polarographically, in comparison with occurance of gastric ulceration and with secretory responses, during gastric ulceration by pyloric ligation. The vol ume of gastric secretion and the number of ulcer occurance were found to increase in period of 7-24 h after pyloric ligation; meanwhile no increase of HCl secretion was found in that time period. The significant increase of glycoproteins in both parts of the stomach wall was found to be present in period of 0-7 h, and also of 7-24 h, after pyloric libation. Alterations of glycoproteins are greater and appear sooner after pyloric ligation, but before occurance of gastric ulceration, in the rumenal part of the stomach wall than in the glandular one. The interrelationship was discussed between the ulcer occurance and increase of glycoproteins prepared from glandular and membranous parts of the stomach wall of rats during development of gastric ulceration by pyloric ligation.

Original languageEnglish
Pages (from-to)253-260
Number of pages8
JournalDigestion
Volume5
Issue number5
DOIs
Publication statusPublished - Jan 1 1972

Keywords

  • Adenosine triphosphate
  • Gastric acidity determination
  • Gastric mucosa
  • Glycoproteins
  • Mucus
  • Peptic ulcer
  • Polarography
  • Rats

ASJC Scopus subject areas

  • Gastroenterology

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