Változások a szív kontraktilis fehérjé inek szerkezetében diasztolés szívelégtelensé g során

Translated title of the contribution: Alterations in myocardial contractile protein composition in diastolic heart failure

Research output: Contribution to journalArticle

Abstract

Disturbances in ventricular relaxation may lead to the development of diastolic heart failure. The analysis of left ventricular endomyocardial biopsy specimens may help understand the underlying structural and functional changes. Such analyses have lead to the recognition that at the optimal sarcomere length of the Frank-Starling mechanism (i.e., at 2.2 μm), passive force values of the cardiomyocytes are significantly higher in individuals with diastolic heart failure than in healthy controls. As a probable explanation to this finding, increased expression of the stiffer N2B isoform of the myofilamental titin protein, at the expense of the more elastic N2BA titin isoform, has been recognized. Moreover, decreased phosphorylation of the contractile proteins was also suggested to contribute to the development of diastolic heart failure. These changes together, and along with an increase in extracellular collagen content, may greatly contribute to the relaxation disturbance observed in diastolic heart failure.

Translated title of the contributionAlterations in myocardial contractile protein composition in diastolic heart failure
Original languageHungarian
Pages (from-to)441-445
Number of pages5
JournalLege Artis Medicinae
Volume17
Issue number6-7
Publication statusPublished - Jul 1 2007

ASJC Scopus subject areas

  • Medicine(all)

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