Alterations in hepatic lobar function in regenerating rat liver

András Fülöp, András Budai, Zoltán Czigány, G. Lotz, Katalin Dezso, S. Paku, László Harsányi, Attila Szijártó

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background Ligation of a branch of the portal vein redirects portal blood to nonligated lobes resulting in lobar hypertrophy. Although the effect of portal vein ligation on liver volume is well documented, the parallel alterations in liver function are still the subject of controversy. Our aim was to assess the time-dependent reactions of regional hepatic function to portal vein ligation by selective biliary drainage. Methods Male Wistar rats (n = 44) underwent 80% portal vein ligation. Before the operation as well as 1, 2, 3, 5, and 7 d after circulation, morphology and function (laboratory blood test; hepatic bile flow; plasma disappearance rate of indocyanine green; and biliary indocyanine green excretion) of the liver were examined. Results Although portal vein ligation affected liver circulation and morphology to a great extent, serum albumin levels, bilirubin levels, and total hepatic bile flow did not change significantly after the operation. Nevertheless, plasma disappearance rate and biliary indocyanine green excretion indicated a temporary impairment of total liver function with the lowest value on the second day and normalization by the fifth day. Bile production and biliary indocyanine green excretion of ligated lobes decreased rapidly after the operation and remained persistently suppressed, whereas the secretory function of nonligated lobes - after a temporary decline - showed a greater increase than the weight of the lobes. Conclusions Portal vein ligation induced temporary impairment of total liver function, followed by rapid recovery mainly by reason of increase in the function of nonligated lobes. Functional increase in nonligated lobes was more pronounced than suggested by the degree of volume gain.

Original languageEnglish
Pages (from-to)307-317
Number of pages11
JournalJournal of Surgical Research
Volume197
Issue number2
DOIs
Publication statusPublished - Aug 1 2015

Fingerprint

Portal Vein
Ligation
Indocyanine Green
Liver
Bile
Liver Circulation
Hematologic Tests
Bilirubin
Serum Albumin
Hypertrophy
Wistar Rats
Drainage
Weights and Measures

Keywords

  • Bile flow
  • Indocyanine green
  • Liver function
  • Liver regeneration
  • Portal vein ligation

ASJC Scopus subject areas

  • Surgery

Cite this

Alterations in hepatic lobar function in regenerating rat liver. / Fülöp, András; Budai, András; Czigány, Zoltán; Lotz, G.; Dezso, Katalin; Paku, S.; Harsányi, László; Szijártó, Attila.

In: Journal of Surgical Research, Vol. 197, No. 2, 01.08.2015, p. 307-317.

Research output: Contribution to journalArticle

Fülöp, A, Budai, A, Czigány, Z, Lotz, G, Dezso, K, Paku, S, Harsányi, L & Szijártó, A 2015, 'Alterations in hepatic lobar function in regenerating rat liver', Journal of Surgical Research, vol. 197, no. 2, pp. 307-317. https://doi.org/10.1016/j.jss.2015.04.033
Fülöp, András ; Budai, András ; Czigány, Zoltán ; Lotz, G. ; Dezso, Katalin ; Paku, S. ; Harsányi, László ; Szijártó, Attila. / Alterations in hepatic lobar function in regenerating rat liver. In: Journal of Surgical Research. 2015 ; Vol. 197, No. 2. pp. 307-317.
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abstract = "Background Ligation of a branch of the portal vein redirects portal blood to nonligated lobes resulting in lobar hypertrophy. Although the effect of portal vein ligation on liver volume is well documented, the parallel alterations in liver function are still the subject of controversy. Our aim was to assess the time-dependent reactions of regional hepatic function to portal vein ligation by selective biliary drainage. Methods Male Wistar rats (n = 44) underwent 80{\%} portal vein ligation. Before the operation as well as 1, 2, 3, 5, and 7 d after circulation, morphology and function (laboratory blood test; hepatic bile flow; plasma disappearance rate of indocyanine green; and biliary indocyanine green excretion) of the liver were examined. Results Although portal vein ligation affected liver circulation and morphology to a great extent, serum albumin levels, bilirubin levels, and total hepatic bile flow did not change significantly after the operation. Nevertheless, plasma disappearance rate and biliary indocyanine green excretion indicated a temporary impairment of total liver function with the lowest value on the second day and normalization by the fifth day. Bile production and biliary indocyanine green excretion of ligated lobes decreased rapidly after the operation and remained persistently suppressed, whereas the secretory function of nonligated lobes - after a temporary decline - showed a greater increase than the weight of the lobes. Conclusions Portal vein ligation induced temporary impairment of total liver function, followed by rapid recovery mainly by reason of increase in the function of nonligated lobes. Functional increase in nonligated lobes was more pronounced than suggested by the degree of volume gain.",
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AU - Czigány, Zoltán

AU - Lotz, G.

AU - Dezso, Katalin

AU - Paku, S.

AU - Harsányi, László

AU - Szijártó, Attila

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N2 - Background Ligation of a branch of the portal vein redirects portal blood to nonligated lobes resulting in lobar hypertrophy. Although the effect of portal vein ligation on liver volume is well documented, the parallel alterations in liver function are still the subject of controversy. Our aim was to assess the time-dependent reactions of regional hepatic function to portal vein ligation by selective biliary drainage. Methods Male Wistar rats (n = 44) underwent 80% portal vein ligation. Before the operation as well as 1, 2, 3, 5, and 7 d after circulation, morphology and function (laboratory blood test; hepatic bile flow; plasma disappearance rate of indocyanine green; and biliary indocyanine green excretion) of the liver were examined. Results Although portal vein ligation affected liver circulation and morphology to a great extent, serum albumin levels, bilirubin levels, and total hepatic bile flow did not change significantly after the operation. Nevertheless, plasma disappearance rate and biliary indocyanine green excretion indicated a temporary impairment of total liver function with the lowest value on the second day and normalization by the fifth day. Bile production and biliary indocyanine green excretion of ligated lobes decreased rapidly after the operation and remained persistently suppressed, whereas the secretory function of nonligated lobes - after a temporary decline - showed a greater increase than the weight of the lobes. Conclusions Portal vein ligation induced temporary impairment of total liver function, followed by rapid recovery mainly by reason of increase in the function of nonligated lobes. Functional increase in nonligated lobes was more pronounced than suggested by the degree of volume gain.

AB - Background Ligation of a branch of the portal vein redirects portal blood to nonligated lobes resulting in lobar hypertrophy. Although the effect of portal vein ligation on liver volume is well documented, the parallel alterations in liver function are still the subject of controversy. Our aim was to assess the time-dependent reactions of regional hepatic function to portal vein ligation by selective biliary drainage. Methods Male Wistar rats (n = 44) underwent 80% portal vein ligation. Before the operation as well as 1, 2, 3, 5, and 7 d after circulation, morphology and function (laboratory blood test; hepatic bile flow; plasma disappearance rate of indocyanine green; and biliary indocyanine green excretion) of the liver were examined. Results Although portal vein ligation affected liver circulation and morphology to a great extent, serum albumin levels, bilirubin levels, and total hepatic bile flow did not change significantly after the operation. Nevertheless, plasma disappearance rate and biliary indocyanine green excretion indicated a temporary impairment of total liver function with the lowest value on the second day and normalization by the fifth day. Bile production and biliary indocyanine green excretion of ligated lobes decreased rapidly after the operation and remained persistently suppressed, whereas the secretory function of nonligated lobes - after a temporary decline - showed a greater increase than the weight of the lobes. Conclusions Portal vein ligation induced temporary impairment of total liver function, followed by rapid recovery mainly by reason of increase in the function of nonligated lobes. Functional increase in nonligated lobes was more pronounced than suggested by the degree of volume gain.

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