Alterations in glial fibrillary acidic protein immunoreactivity in the upper dorsal horn of the rat spinal cord in the course of transganglionic degenerative atrophy and regenerative proliferation

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Transection of a peripheral nerve induces marked increase in the glial fibrillary acidic protein (GFAP) immunoreactivity in the ipsilateral, segmentally related upper dorsal horn. Increase of GFAP immunoreaction is similar to, but not identical with, that observed after dorsal rhizotomy. If the peripheral nerve succeeds in regenerating, GFAP immunoreactivity in the upper dorsal horn returns to normal. It is concluded that the amount and distribution of GFAP is determined by transganglionic degenerative atrophy, Wallerian degeneration and regenerative proliferation of dorsal root axon terminals, respectively.

Original languageEnglish
Pages (from-to)8-13
Number of pages6
JournalNeuroscience Letters
Volume117
Issue number1-2
DOIs
Publication statusPublished - Sep 4 1990

Fingerprint

Glial Fibrillary Acidic Protein
Atrophy
Peripheral Nerves
Rhizotomy
Wallerian Degeneration
Spinal Nerve Roots
Presynaptic Terminals
Spinal Cord Dorsal Horn

Keywords

  • Axotomy
  • Degeneration
  • Glial fibrillary acidic protein
  • Regeneration
  • Rhizotomy
  • Spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{3adf1a168c964c7c8c801d19a446ec12,
title = "Alterations in glial fibrillary acidic protein immunoreactivity in the upper dorsal horn of the rat spinal cord in the course of transganglionic degenerative atrophy and regenerative proliferation",
abstract = "Transection of a peripheral nerve induces marked increase in the glial fibrillary acidic protein (GFAP) immunoreactivity in the ipsilateral, segmentally related upper dorsal horn. Increase of GFAP immunoreaction is similar to, but not identical with, that observed after dorsal rhizotomy. If the peripheral nerve succeeds in regenerating, GFAP immunoreactivity in the upper dorsal horn returns to normal. It is concluded that the amount and distribution of GFAP is determined by transganglionic degenerative atrophy, Wallerian degeneration and regenerative proliferation of dorsal root axon terminals, respectively.",
keywords = "Axotomy, Degeneration, Glial fibrillary acidic protein, Regeneration, Rhizotomy, Spinal cord",
author = "Ferenc Haj{\'o}s and B. Csillik and E. Knyih{\'a}r-Csillik",
year = "1990",
month = "9",
day = "4",
doi = "10.1016/0304-3940(90)90111-L",
language = "English",
volume = "117",
pages = "8--13",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Alterations in glial fibrillary acidic protein immunoreactivity in the upper dorsal horn of the rat spinal cord in the course of transganglionic degenerative atrophy and regenerative proliferation

AU - Hajós, Ferenc

AU - Csillik, B.

AU - Knyihár-Csillik, E.

PY - 1990/9/4

Y1 - 1990/9/4

N2 - Transection of a peripheral nerve induces marked increase in the glial fibrillary acidic protein (GFAP) immunoreactivity in the ipsilateral, segmentally related upper dorsal horn. Increase of GFAP immunoreaction is similar to, but not identical with, that observed after dorsal rhizotomy. If the peripheral nerve succeeds in regenerating, GFAP immunoreactivity in the upper dorsal horn returns to normal. It is concluded that the amount and distribution of GFAP is determined by transganglionic degenerative atrophy, Wallerian degeneration and regenerative proliferation of dorsal root axon terminals, respectively.

AB - Transection of a peripheral nerve induces marked increase in the glial fibrillary acidic protein (GFAP) immunoreactivity in the ipsilateral, segmentally related upper dorsal horn. Increase of GFAP immunoreaction is similar to, but not identical with, that observed after dorsal rhizotomy. If the peripheral nerve succeeds in regenerating, GFAP immunoreactivity in the upper dorsal horn returns to normal. It is concluded that the amount and distribution of GFAP is determined by transganglionic degenerative atrophy, Wallerian degeneration and regenerative proliferation of dorsal root axon terminals, respectively.

KW - Axotomy

KW - Degeneration

KW - Glial fibrillary acidic protein

KW - Regeneration

KW - Rhizotomy

KW - Spinal cord

UR - http://www.scopus.com/inward/record.url?scp=0025043120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025043120&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(90)90111-L

DO - 10.1016/0304-3940(90)90111-L

M3 - Article

VL - 117

SP - 8

EP - 13

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -