Alteration of serum semicarbazide-sensitive amine oxidase activity in chronic renal failure

J. Nemcsik, É. Szökő, Zs Soltész, E. Fodor, L. Toth, J. Egresits, T. Tábi, K. Magyar, I. Kiss

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Despite recent intensive investigations, physiological and pathological role of semicarbazide-sensitive amine oxidase (SSAO) is far from clear. In this study, serum SSAO activity was determined, radiochemically, in various groups of uremic patients: haemodialysed (HD), peritoneally dialysed (PD) and those receiving conservative treatment but still not dialysed (ND), as well as in controls. Reduced enzyme activity was found in HD uremic patients before and after dialysis treatment, compared to controls (5260 ± 862 and 6011 ± 958pmol/h/ml vs. 8601 ± 283pmol/h/ml, p <0.01 and p <0.05, respectively). The activity was slightly lower in PD, and normal in ND patients. In HD patients SSAO activity was also determined by an assay based on the formation of hydrogen peroxide, and was found to be elevated compared to controls (2384 ± 323pmol/h/ml vs. 1437 ± 72pmol/h/ml, p <0.05). The elevated serum SSAO activity measured through the detection of the enzyme-generated hydrogen peroxide in HD patients might indicate its contribution to the accelerated atherosclerotic disease observed in uremia.

Original languageEnglish
Pages (from-to)841-843
Number of pages3
JournalJournal of Neural Transmission
Volume114
Issue number6
DOIs
Publication statusPublished - Jun 2007

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Amine Oxidase (Copper-Containing)
Chronic Kidney Failure
Serum
Hydrogen Peroxide
Uremia
Enzymes
Dialysis

Keywords

  • Atherosclerotic disease
  • Benzylamine
  • Haemodialysis
  • Methylamine
  • Peritoneal dialysis
  • Renal failure
  • Semicarbazide-sensitive amine oxidase
  • Uremia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alteration of serum semicarbazide-sensitive amine oxidase activity in chronic renal failure. / Nemcsik, J.; Szökő, É.; Soltész, Zs; Fodor, E.; Toth, L.; Egresits, J.; Tábi, T.; Magyar, K.; Kiss, I.

In: Journal of Neural Transmission, Vol. 114, No. 6, 06.2007, p. 841-843.

Research output: Contribution to journalArticle

Nemcsik, J. ; Szökő, É. ; Soltész, Zs ; Fodor, E. ; Toth, L. ; Egresits, J. ; Tábi, T. ; Magyar, K. ; Kiss, I. / Alteration of serum semicarbazide-sensitive amine oxidase activity in chronic renal failure. In: Journal of Neural Transmission. 2007 ; Vol. 114, No. 6. pp. 841-843.
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