Alteration of protease levels in different brain areas of suicide victims

Miriam Banay-Schwartz, Teresita DeGuzman, G. Faludi, Abel Lajtha, M. Palkóvits

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Numerous recent studies found that proteases play a major role in brain function. In addition to their role in protein turnover, they have modulatory functions and an important role in apoptosis, pathological changes, and other mechanisms. To explore possible differences in brain protein metabolism of suicide victims, we examined the activity of two proteases, cathepsin D and calpain (I and II combined), in eleven discrete areas of postmortem brain tissue of 21 victims of suicide and of 31 age- and sex-matched control subjects without a history of psychiatric or neurological disease. The levels of functionally important amino acids in five of these areas were also measured. Cathepsin D activity was found to be lower in two of eleven regions of brains of suicide victims, the parahippocampal cortex and the medial hypothalamus, by 26% and 27%, respectively. Calpain activity was lower in two different areas tested, 29% in the medulla oblongata and 26% in the lateral prefrontal cortex, and was 18% higher in the midbrain. There were no significant differences in the other areas (globus pallidus, hippocampus, amygdala, caudate nucleus, ventral tegmental area, and nucleus accumbens). Protease distribution was regionally heterogeneous - the levels in the globus pallidus were low, and in the hippocampus high, with about a two-fold difference. The length of the postmortem period for obtaining tissue, the storage time of the frozen tissue, and the age of the subject had no apparent influence on the results obtained. Although there was a tendency toward higher levels of aspartate and glycine in brain areas from suicide victims, the difference was not significant. The variations among individual brains were greater in amino acid levels than in protease levels. The findings indicate the possible role of protein metabolism in depressive or suicidal behavior.

Original languageEnglish
Pages (from-to)953-959
Number of pages7
JournalNeurochemical Research
Volume23
Issue number7
DOIs
Publication statusPublished - 1998

Fingerprint

Suicide
Brain
Peptide Hydrolases
Calpain
Cathepsin D
Globus Pallidus
Tissue
Metabolism
Hippocampus
Tegmentum Mesencephali
Middle Hypothalamus
Amino Acids
Medulla Oblongata
Ventral Tegmental Area
Proteins
Caudate Nucleus
Nucleus Accumbens
Mesencephalon
Amygdala
Prefrontal Cortex

Keywords

  • Brain areas
  • Calpain activity
  • Cathepsin D activity
  • Changes in brain in suicide
  • Human brain proteases
  • Suicide brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Alteration of protease levels in different brain areas of suicide victims. / Banay-Schwartz, Miriam; DeGuzman, Teresita; Faludi, G.; Lajtha, Abel; Palkóvits, M.

In: Neurochemical Research, Vol. 23, No. 7, 1998, p. 953-959.

Research output: Contribution to journalArticle

Banay-Schwartz, Miriam ; DeGuzman, Teresita ; Faludi, G. ; Lajtha, Abel ; Palkóvits, M. / Alteration of protease levels in different brain areas of suicide victims. In: Neurochemical Research. 1998 ; Vol. 23, No. 7. pp. 953-959.
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