Alteration of intracellular potassium and sodium concentrations correlates with induction of cytopathic effects by human immunodeficiency virus

Thomas G. Voss, Cesar D. Fermin, Jay A. Levy, Sandor Vigh, Bongkun Choi, Robert F. Garry

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Increases in intracellular concentrations of potassium ([K+](i)) and sodium ([Na+](i)) occur concomitantly with cytopathic effects induced in a CD4+ T-lymphoblastoid cell line acutely infected by human immunodeficiency virus (HIV). This [K+](i) increase was greater in cells infected by cytopathic HIV strains than in cells infected by less cytopathic strains. T cells persistently infected by HIV had an increased [K+](i) but displayed an [Na+](i) similar to that of mock-infected cells. HIV induced increases in [K+](i) and [Na+](i) after cytopathic infection of human peripheral blood mononuclear cells, but the magnitude of the Na+ changes did not correlate with the extent of the cytopathic effect. Enhanced movement of cations may osmotically drive water entry, resulting in balloon degeneration and lysis of HIV-infected cells. These observations offer potential approaches for antiviral therapies.

Original languageEnglish
Pages (from-to)5447-5454
Number of pages8
JournalJournal of Virology
Volume70
Issue number8
Publication statusPublished - Aug 1996

Fingerprint

cytopathogenicity
Human immunodeficiency virus
Potassium
Sodium
potassium
sodium
HIV
T-lymphocytes
cells
mononuclear leukocytes
Antiviral Agents
Cations
Blood Cells
cations
cell lines
T-Lymphocytes
Cell Line
therapeutics
Water
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Alteration of intracellular potassium and sodium concentrations correlates with induction of cytopathic effects by human immunodeficiency virus. / Voss, Thomas G.; Fermin, Cesar D.; Levy, Jay A.; Vigh, Sandor; Choi, Bongkun; Garry, Robert F.

In: Journal of Virology, Vol. 70, No. 8, 08.1996, p. 5447-5454.

Research output: Contribution to journalArticle

Voss, Thomas G. ; Fermin, Cesar D. ; Levy, Jay A. ; Vigh, Sandor ; Choi, Bongkun ; Garry, Robert F. / Alteration of intracellular potassium and sodium concentrations correlates with induction of cytopathic effects by human immunodeficiency virus. In: Journal of Virology. 1996 ; Vol. 70, No. 8. pp. 5447-5454.
@article{82d5eb44755a468abe82bffd5643ebc7,
title = "Alteration of intracellular potassium and sodium concentrations correlates with induction of cytopathic effects by human immunodeficiency virus",
abstract = "Increases in intracellular concentrations of potassium ([K+](i)) and sodium ([Na+](i)) occur concomitantly with cytopathic effects induced in a CD4+ T-lymphoblastoid cell line acutely infected by human immunodeficiency virus (HIV). This [K+](i) increase was greater in cells infected by cytopathic HIV strains than in cells infected by less cytopathic strains. T cells persistently infected by HIV had an increased [K+](i) but displayed an [Na+](i) similar to that of mock-infected cells. HIV induced increases in [K+](i) and [Na+](i) after cytopathic infection of human peripheral blood mononuclear cells, but the magnitude of the Na+ changes did not correlate with the extent of the cytopathic effect. Enhanced movement of cations may osmotically drive water entry, resulting in balloon degeneration and lysis of HIV-infected cells. These observations offer potential approaches for antiviral therapies.",
author = "Voss, {Thomas G.} and Fermin, {Cesar D.} and Levy, {Jay A.} and Sandor Vigh and Bongkun Choi and Garry, {Robert F.}",
year = "1996",
month = "8",
language = "English",
volume = "70",
pages = "5447--5454",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "8",

}

TY - JOUR

T1 - Alteration of intracellular potassium and sodium concentrations correlates with induction of cytopathic effects by human immunodeficiency virus

AU - Voss, Thomas G.

AU - Fermin, Cesar D.

AU - Levy, Jay A.

AU - Vigh, Sandor

AU - Choi, Bongkun

AU - Garry, Robert F.

PY - 1996/8

Y1 - 1996/8

N2 - Increases in intracellular concentrations of potassium ([K+](i)) and sodium ([Na+](i)) occur concomitantly with cytopathic effects induced in a CD4+ T-lymphoblastoid cell line acutely infected by human immunodeficiency virus (HIV). This [K+](i) increase was greater in cells infected by cytopathic HIV strains than in cells infected by less cytopathic strains. T cells persistently infected by HIV had an increased [K+](i) but displayed an [Na+](i) similar to that of mock-infected cells. HIV induced increases in [K+](i) and [Na+](i) after cytopathic infection of human peripheral blood mononuclear cells, but the magnitude of the Na+ changes did not correlate with the extent of the cytopathic effect. Enhanced movement of cations may osmotically drive water entry, resulting in balloon degeneration and lysis of HIV-infected cells. These observations offer potential approaches for antiviral therapies.

AB - Increases in intracellular concentrations of potassium ([K+](i)) and sodium ([Na+](i)) occur concomitantly with cytopathic effects induced in a CD4+ T-lymphoblastoid cell line acutely infected by human immunodeficiency virus (HIV). This [K+](i) increase was greater in cells infected by cytopathic HIV strains than in cells infected by less cytopathic strains. T cells persistently infected by HIV had an increased [K+](i) but displayed an [Na+](i) similar to that of mock-infected cells. HIV induced increases in [K+](i) and [Na+](i) after cytopathic infection of human peripheral blood mononuclear cells, but the magnitude of the Na+ changes did not correlate with the extent of the cytopathic effect. Enhanced movement of cations may osmotically drive water entry, resulting in balloon degeneration and lysis of HIV-infected cells. These observations offer potential approaches for antiviral therapies.

UR - http://www.scopus.com/inward/record.url?scp=0029931718&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029931718&partnerID=8YFLogxK

M3 - Article

VL - 70

SP - 5447

EP - 5454

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 8

ER -