Alteration of ergosterol content and chitin synthase activity in Candida albicans

Miklós Pesti, John M. Campbell, John F. Peberdy

Research output: Contribution to journalArticle

36 Citations (Scopus)


Chitin synthase activity in total membrane fractions from two polyene-resistant, ergosterol-deficient mutants of Candida albicans was significantly higher in comparison to the parental polyene-sensitive strain. The zymogen component from membrane preparations of stationaryphase cells of ergosterol mutants was more susceptible to trypsin digestion than those from the parental polyene-sensitive strain. Mechanisms that might explain the effect of changes in membrane composition in the mutant strains on chitin synthase activity are discussed.

Original languageEnglish
Pages (from-to)187-190
Number of pages4
JournalCurrent Microbiology
Issue number3
Publication statusPublished - May 1 1981

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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