Alteration of aminoacyl tRNA synthetases with age: Accumulation of heat-labile enzyme molecules in rat liver, kidney and brain

Ryoya Takahashi, Nozomu Mori, S. Goto

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Age-related changes of aminoacyl tRNA synthetases were investigated in tissues from 3- to 24-month-old rats. The proportions of heat-labile enzymes in the liver, kidney and brain were 0-20% in young animals, but 15-40% in old animals. The proportions of heat-labile enzymes increase from about 15 months of age when the probability of death also increases greatly. These findings suggest that decrease in functional activities of various tissues in old animals is in some way related to the accumulation of these altered proteins.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalMechanisms of Ageing and Development
Volume33
Issue number1
DOIs
Publication statusPublished - 1985

Fingerprint

Amino Acyl-tRNA Synthetases
Liver
Rats
Brain
Animals
Hot Temperature
Kidney
Molecules
Enzymes
Tissue
Proteins

Keywords

  • Ageing
  • Altered enzyme
  • Aminoacyl tRNA synthetase
  • Heat-stability
  • Rat

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Alteration of aminoacyl tRNA synthetases with age : Accumulation of heat-labile enzyme molecules in rat liver, kidney and brain. / Takahashi, Ryoya; Mori, Nozomu; Goto, S.

In: Mechanisms of Ageing and Development, Vol. 33, No. 1, 1985, p. 67-75.

Research output: Contribution to journalArticle

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