Egy multifunkcionális fehérje

az ALR

Translated title of the contribution: ALR, the multifunctional protein

Tibor Balogh, A. Szarka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

ALR is a mystic protein. It has a so called "long" 22 kDa and a "short" 15 kDa forms. It has been described after partial hepatectomy and it has just been considered as a key protein of liver regeneration. At the beginning of the 21st century it has been revealed that the "long" form is localized in the mitochondrial intermembrane space and it is an element of the mitochondrial protein import and disulphide relay system. Several proteins of the substrates of the mitochondrial disulphide relay system are necessary for the proper function of the mitochondria, thus any mutation of the ALR gene leads to mitochondrial diseases. The "short" form of ALR functions as a secreted extracellular growth factor and it promotes the protection, regeneration and proliferation of hepatocytes. The results gained on the recently generated conditional ALR mutant mice suggest that ALR can play an important role in the pathogenesis of alcoholic and non-Alcoholic steatosis. Since the serum level of ALR is modified in several liver diseases it can be a promising marker molecule in laboratory diagnostics.

Original languageHungarian
Pages (from-to)503-509
Number of pages7
JournalOrvosi Hetilap
Volume156
Issue number13
DOIs
Publication statusPublished - Mar 1 2015

Fingerprint

Mitochondrial Proteins
Disulfides
Mitochondrial Diseases
Liver Regeneration
Hepatectomy
Liver Diseases
Regeneration
Hepatocytes
Intercellular Signaling Peptides and Proteins
Mitochondria
Proteins
Mutation
Serum
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Egy multifunkcionális fehérje : az ALR. / Balogh, Tibor; Szarka, A.

In: Orvosi Hetilap, Vol. 156, No. 13, 01.03.2015, p. 503-509.

Research output: Contribution to journalArticle

Balogh, Tibor ; Szarka, A. / Egy multifunkcionális fehérje : az ALR. In: Orvosi Hetilap. 2015 ; Vol. 156, No. 13. pp. 503-509.
@article{3a5b0db268ce4a19b8232f4102df22bc,
title = "Egy multifunkcion{\'a}lis feh{\'e}rje: az ALR",
abstract = "ALR is a mystic protein. It has a so called {"}long{"} 22 kDa and a {"}short{"} 15 kDa forms. It has been described after partial hepatectomy and it has just been considered as a key protein of liver regeneration. At the beginning of the 21st century it has been revealed that the {"}long{"} form is localized in the mitochondrial intermembrane space and it is an element of the mitochondrial protein import and disulphide relay system. Several proteins of the substrates of the mitochondrial disulphide relay system are necessary for the proper function of the mitochondria, thus any mutation of the ALR gene leads to mitochondrial diseases. The {"}short{"} form of ALR functions as a secreted extracellular growth factor and it promotes the protection, regeneration and proliferation of hepatocytes. The results gained on the recently generated conditional ALR mutant mice suggest that ALR can play an important role in the pathogenesis of alcoholic and non-Alcoholic steatosis. Since the serum level of ALR is modified in several liver diseases it can be a promising marker molecule in laboratory diagnostics.",
keywords = "ALR, ALR, liver, mitochondria, mitokondrium, m{\'a}j, oxidative folding, oxidat{\'i}v folding, steatosis, steatosis",
author = "Tibor Balogh and A. Szarka",
year = "2015",
month = "3",
day = "1",
doi = "10.1556/OH.2015.30119",
language = "Hungarian",
volume = "156",
pages = "503--509",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "13",

}

TY - JOUR

T1 - Egy multifunkcionális fehérje

T2 - az ALR

AU - Balogh, Tibor

AU - Szarka, A.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - ALR is a mystic protein. It has a so called "long" 22 kDa and a "short" 15 kDa forms. It has been described after partial hepatectomy and it has just been considered as a key protein of liver regeneration. At the beginning of the 21st century it has been revealed that the "long" form is localized in the mitochondrial intermembrane space and it is an element of the mitochondrial protein import and disulphide relay system. Several proteins of the substrates of the mitochondrial disulphide relay system are necessary for the proper function of the mitochondria, thus any mutation of the ALR gene leads to mitochondrial diseases. The "short" form of ALR functions as a secreted extracellular growth factor and it promotes the protection, regeneration and proliferation of hepatocytes. The results gained on the recently generated conditional ALR mutant mice suggest that ALR can play an important role in the pathogenesis of alcoholic and non-Alcoholic steatosis. Since the serum level of ALR is modified in several liver diseases it can be a promising marker molecule in laboratory diagnostics.

AB - ALR is a mystic protein. It has a so called "long" 22 kDa and a "short" 15 kDa forms. It has been described after partial hepatectomy and it has just been considered as a key protein of liver regeneration. At the beginning of the 21st century it has been revealed that the "long" form is localized in the mitochondrial intermembrane space and it is an element of the mitochondrial protein import and disulphide relay system. Several proteins of the substrates of the mitochondrial disulphide relay system are necessary for the proper function of the mitochondria, thus any mutation of the ALR gene leads to mitochondrial diseases. The "short" form of ALR functions as a secreted extracellular growth factor and it promotes the protection, regeneration and proliferation of hepatocytes. The results gained on the recently generated conditional ALR mutant mice suggest that ALR can play an important role in the pathogenesis of alcoholic and non-Alcoholic steatosis. Since the serum level of ALR is modified in several liver diseases it can be a promising marker molecule in laboratory diagnostics.

KW - ALR

KW - ALR

KW - liver

KW - mitochondria

KW - mitokondrium

KW - máj

KW - oxidative folding

KW - oxidatív folding

KW - steatosis

KW - steatosis

UR - http://www.scopus.com/inward/record.url?scp=84925652371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925652371&partnerID=8YFLogxK

U2 - 10.1556/OH.2015.30119

DO - 10.1556/OH.2015.30119

M3 - Article

VL - 156

SP - 503

EP - 509

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 13

ER -