Alpha2 antagonist yohimbine suppresses maintained firing of rat prefrontal neurons in vivo

Péter Kovács, I. Hernádi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

As a general α2 adrenergic antagonist, yohimbine has been widely used for research needs and in the therapy of malfunction of the noradrenergic system. In this study we analysed the effects of iontophoretically applied yohimbine on 79 prefrontal cortical (PFC) neurons of the rat in vivo. Our results indicate the inhibitory effect of norepinephrine on PFC neurons, which was simulated by yohimbine. The effect of yohimbine was not blocked by known α1 or postsynaptic α2 receptor agents. These results indicate that yohimbine exerts its antagonising and hyperpolarising effect on presynaptic rather than postsynaptic α2 receptors. Since these receptors have a permissive role in maintaining neural activity, their malfunction may contribute to the behavioural deficits observed in prefrontal disorders.

Original languageEnglish
Pages (from-to)833-836
Number of pages4
JournalNeuroReport
Volume14
Issue number6
DOIs
Publication statusPublished - May 6 2003

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Yohimbine
Neurons
Adrenergic Antagonists
Norepinephrine
Research

Keywords

  • α2 Adrenoceptors
  • Electrophysiology
  • Iontophoresis
  • Norepinephrine
  • Prefrontal Cortex
  • Yohimbine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alpha2 antagonist yohimbine suppresses maintained firing of rat prefrontal neurons in vivo. / Kovács, Péter; Hernádi, I.

In: NeuroReport, Vol. 14, No. 6, 06.05.2003, p. 833-836.

Research output: Contribution to journalArticle

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