Alpha-lactalbumin acts as a bimodal regulator of rat parotid acinar cell growth

Michael G. Humphreys-Beher, Charlotte A. Schneyer, T. Zelles

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Isoproterenol, a β-adrenergic receptor agonist, causes hypertrophy and hyperplasia of the rat parotid gland. The stimulation of parotid acinar cells to a growth phase is accompanied by a cell surface localization of the enzyme 4β-galactosyltransferase. Alpha-lactalbumin, a specific modifier protein for 4β-galactosyltransferase, when given subsequent to the initiation of isoproterenol treatment and the commencement of parotid enlargement, resulted in a termination of gland hypertrophy and DNA synthesis. Gland size did not, however, return to control levels with the continued injection of isoproterenol and alpha- lactalbumin. In contrast, the injection of alpha-lactalbumin in neonatal rats (7-14 days post-partum) stimulated parotid gland hypertrophy and DNA synthesis. This treatment also lead to the precocious expression of the major parotid gland salivary enzyme, amylase.

Original languageEnglish
Pages (from-to)174-181
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume147
Issue number1
DOIs
Publication statusPublished - Aug 31 1987

Fingerprint

Lactalbumin
Acinar Cells
Parotid Gland
Cell growth
Isoproterenol
Hypertrophy
Galactosyltransferases
Rats
Growth
Adrenergic Agonists
Injections
DNA
Level control
Enzymes
Amylases
Hyperplasia
Therapeutics
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Alpha-lactalbumin acts as a bimodal regulator of rat parotid acinar cell growth. / Humphreys-Beher, Michael G.; Schneyer, Charlotte A.; Zelles, T.

In: Biochemical and Biophysical Research Communications, Vol. 147, No. 1, 31.08.1987, p. 174-181.

Research output: Contribution to journalArticle

Humphreys-Beher, Michael G. ; Schneyer, Charlotte A. ; Zelles, T. / Alpha-lactalbumin acts as a bimodal regulator of rat parotid acinar cell growth. In: Biochemical and Biophysical Research Communications. 1987 ; Vol. 147, No. 1. pp. 174-181.
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