Alpha-haemolysin: An additive virulence factor in Escherichia coli

L. Emődy, T. Pal, N. V. Safonova, B. Kuch, N. K. Golutva

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Haemolytic Escherichia coli, including human intestinal and extraintestinal as well as porcine enterotoxigenic and edema disease isolates, and Proteus morganii strains were studied for their virulence. Hly+ wild-type strains and Hly+ transconjugants were more virulent than Hly+ derivatives as shown in mice and chick embryos. This enhanced virulence seems to be connected with the ability of diffusible alpha-hemolysin production because clones producing only non-diffusible, beta-hemolysin behaved as non-hemolytic ones. Hemorrhagic lung symptoms and haemoglobinuria were frequently observed after parenteral challenge of mice with alpha-haemolytic clones. Though the Hly- clone exhibited a high resistance against blood clearance, the number of circulating bacteria was significantly higher in the case of the alpha-haemolytic clone. A causal connection between this phenomenon and the leukocidin activity of alpha-haemolysin is suggested.

Original languageEnglish
Pages (from-to)333-342
Number of pages10
JournalActa Microbiologica Academiae Scientiarum Hungaricae
Volume27
Issue number4
Publication statusPublished - 1980

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Hemolysin Proteins
Virulence Factors
Clone Cells
Escherichia coli
Virulence
Hemoglobinuria
Leukocidins
Proteus
Chick Embryo
Edema
Swine
Bacteria
Lung

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Alpha-haemolysin : An additive virulence factor in Escherichia coli. / Emődy, L.; Pal, T.; Safonova, N. V.; Kuch, B.; Golutva, N. K.

In: Acta Microbiologica Academiae Scientiarum Hungaricae, Vol. 27, No. 4, 1980, p. 333-342.

Research output: Contribution to journalArticle

Emődy, L, Pal, T, Safonova, NV, Kuch, B & Golutva, NK 1980, 'Alpha-haemolysin: An additive virulence factor in Escherichia coli', Acta Microbiologica Academiae Scientiarum Hungaricae, vol. 27, no. 4, pp. 333-342.
Emődy, L. ; Pal, T. ; Safonova, N. V. ; Kuch, B. ; Golutva, N. K. / Alpha-haemolysin : An additive virulence factor in Escherichia coli. In: Acta Microbiologica Academiae Scientiarum Hungaricae. 1980 ; Vol. 27, No. 4. pp. 333-342.
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