Alpha-2-macroglobulin intronic polymorphism is not associated with autopsy-confirmed late-onset Alzheimer's disease

Tibor Kovács, Nigel J. Cairns, Peter L. Lantos

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Alpha-2-macroglobulin (A2M) intronic polymorphism has recently been reported to be associated with late-onset Alzheimer's disease (LOAD). To corroborate this association, we analysed the A2M and apolipoprotein E (APOE) polymorphisms in autopsy cases of the MRC Alzheimer's Disease Brain Bank, Institute of Psychiatry, London. The frequencies of the insertion and deletion alleles in AD were 0.81 and 0.19, respectively, and these were not significantly different from control frequencies. After pooling the AD cases in ε4 positive and negative subgroups, there was again no significant difference between the A2M allele frequency in the two subgroups. In our present study, we were unable to corroborate the association between A2M intronic polymorphism and LOAD in autopsy cases. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalNeuroscience Letters
Volume273
Issue number1
DOIs
Publication statusPublished - Sep 24 1999

Keywords

  • Alpha-2 macroglobulin
  • Alzheimer's disease
  • Apolipoprotein E

ASJC Scopus subject areas

  • Neuroscience(all)

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