Alpha-2 adrenergic and opioid receptor-mediated gastroprotection

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Abstract

Clonidine inhibited the development of gastric mucosal lesions induced by either acidified ethanol or indomethacin. The ED50 values were: 7.1 and 5.2 μg·kg-1 orally, respectively. The gastroprotective effect was antagonised by the pre-synaptic alpha-2 antagonist yohimbine, the more selective alpha-2 antagonist Ch-38083 and the pre-synaptic alpha-2B antagonist prazosin. Moreover, the non-selective opioid receptor antagonist naloxone, the delta receptor selective naltrindole also reversed the clonidine-induced mucosal protective action. Clonidine was also effective following intracerebroventricular administration with the ED50 of 37 ng/rat against ethanol-induced mucosal damage. Our results suggest that: 1) the gastroprotective effect of clonidine is likely to be mediated by alpha-2B adrenoceptor subtype; 2) there is an interaction between pre-synaptic alpha-2 adrenoceptors and opioid system; and 3) clonidine can induce gastroprotection by central mechanism. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalJournal of Physiology Paris
Volume94
Issue number2
DOIs
Publication statusPublished - Mar 2000

Keywords

  • Alpha-2B adrenoceptors
  • Clonidine
  • Gastroprotection
  • Opioid receptors

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

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