Allosamidin inhibits the fragmentation of Acremonium chrysogenum but does not influence the cephalosporin-C production of the fungus

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Abstract

The pseudotrisaccharide allosamidin, a potent inhibitor of chitinases, retarded the fragmentation of hyphae but did not affect the fungal growth and cephalosporin-C production in Acremonium chrysogenum. In vitro inhibition of A. chrysogenum cell-bound chitinase(s) by allosamidin revealed that about 47% of the soluble intracellular chitinase activity was resistant to the inhibitory effect of allosamidin. On the other hand, about 76% of the total chitinase activity localised in both the soluble and insoluble enzyme fractions was effectively inhibited by allosamidin. All the chitinase activities were measured using a new procedure based on purified A. chrysogenum chitin as substrate. Copyright (C) 1998 Federation of European Microbiological Societies Published by Elsevier Scienced B.V. All rights reserved.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalFEMS microbiology letters
Volume164
Issue number2
DOIs
Publication statusPublished - Jul 15 1998

Keywords

  • Acremonium chrysogenum
  • Allosamidin
  • Cephalosporin-C production
  • Chitinase
  • Fragmentation

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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