Alloimmune and autoimmune background in recurrent pregnancy loss - Successful immunotherapy by intravenous immunoglobulin

Beatrix Kotlan, Agnes Padanyi, Jozsef Batorfi, Vilmos Fulop, Ivan Szigetvari, Katalin Rajczy, Maria Penzes, Eva Gyodi, Marienne Reti, Gyozo Petranyi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Problem: Immunotherapies [leukocyte immunization, intravenous immunoglobulin (IVIG)] introduced to treat women with recurrent spontaneous abortions (RSA) have still controversial results in most clinical trials. A selection of these patients would be advantageous for higher efficacy. Method of study: A complex immunological panel assay was offered to patients with reproductive failure without any other known cause. We focused here on the cellular immunological parameters. Results: High cytotoxic T lymphocyte precursor frequency and cell-mediated cytotoxic activity and a rather high natural killer cell activity were found in alloimmune RSA patients. Thirty-two patients were investigated by immunological assays and in 78% of the women an alloimmune background could be defined. The efficacy of IVIG treatment was 96% in this group. Conclusions: The novel cellular immunological assays proved to be favourable for the indication of RSA patients and showed the usefulness of this selection process for effective immunotherapy.

Original languageEnglish
Pages (from-to)331-340
Number of pages10
JournalAmerican Journal of Reproductive Immunology
Volume55
Issue number5
DOIs
Publication statusPublished - May 1 2006

Keywords

  • Cytotoxic T lymphocyte
  • Immunological assay
  • Spontaneous abortion

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

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