Alloimmune and autoimmune background in recurrent pregnancy loss - Successful immunotherapy by intravenous immunoglobulin

Beatrix Kotlan, Agnes Padanyi, Jozsef Batorfi, V. Fülöp, Ivan Szigetvari, K. Rajczy, Maria Penzes, Eva Gyodi, Marienne Reti, G. Petrányi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Problem: Immunotherapies [leukocyte immunization, intravenous immunoglobulin (IVIG)] introduced to treat women with recurrent spontaneous abortions (RSA) have still controversial results in most clinical trials. A selection of these patients would be advantageous for higher efficacy. Method of study: A complex immunological panel assay was offered to patients with reproductive failure without any other known cause. We focused here on the cellular immunological parameters. Results: High cytotoxic T lymphocyte precursor frequency and cell-mediated cytotoxic activity and a rather high natural killer cell activity were found in alloimmune RSA patients. Thirty-two patients were investigated by immunological assays and in 78% of the women an alloimmune background could be defined. The efficacy of IVIG treatment was 96% in this group. Conclusions: The novel cellular immunological assays proved to be favourable for the indication of RSA patients and showed the usefulness of this selection process for effective immunotherapy.

Original languageEnglish
Pages (from-to)331-340
Number of pages10
JournalAmerican Journal of Reproductive Immunology
Volume55
Issue number5
DOIs
Publication statusPublished - May 2006

Fingerprint

Intravenous Immunoglobulins
Habitual Abortion
Immunotherapy
Spontaneous Abortion
Pregnancy
Cytotoxic T-Lymphocytes
Natural Killer Cells
Patient Selection
Immunization
Leukocytes
Clinical Trials
Therapeutics

Keywords

  • Cytotoxic T lymphocyte
  • Immunological assay
  • Spontaneous abortion

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynaecology

Cite this

Alloimmune and autoimmune background in recurrent pregnancy loss - Successful immunotherapy by intravenous immunoglobulin. / Kotlan, Beatrix; Padanyi, Agnes; Batorfi, Jozsef; Fülöp, V.; Szigetvari, Ivan; Rajczy, K.; Penzes, Maria; Gyodi, Eva; Reti, Marienne; Petrányi, G.

In: American Journal of Reproductive Immunology, Vol. 55, No. 5, 05.2006, p. 331-340.

Research output: Contribution to journalArticle

Kotlan, Beatrix ; Padanyi, Agnes ; Batorfi, Jozsef ; Fülöp, V. ; Szigetvari, Ivan ; Rajczy, K. ; Penzes, Maria ; Gyodi, Eva ; Reti, Marienne ; Petrányi, G. / Alloimmune and autoimmune background in recurrent pregnancy loss - Successful immunotherapy by intravenous immunoglobulin. In: American Journal of Reproductive Immunology. 2006 ; Vol. 55, No. 5. pp. 331-340.
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