Over the past few years there have been major advances in the use of peripheral blood stem cells as an alternative to bone marrow in transplantation. Initially these efforts have been focused on autologuos transplants. However the application of peripheral blood stem cell transplantation has now been extended to the allogeneic setting. Adequate mobilization with minimal side-effects can be achieved in normal donors using a short course of granulocyte colony stimulating factor. Allogeneic peripheral stem cells provide long-term engraftment that appears to be more rapid than that has been observed with marrow. The cellular composition of blood cell and marrow allografts is very different. Although the amount of infused T-cells is increased, no difference in acute graft versus host disease has been documented. Allogeneic stem cell transplantation seems to be a viable alternative to bone marrow transplantation and probably will expand both in matched sibling and in mismatched transplantation.
|Translated title of the contribution||Allogeneic peripheral blood stem cell transplantation|
|Number of pages||4|
|Journal||Lege Artis Medicinae|
|Publication status||Published - Oct 2 1997|
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