All-trans-retinoic acid enhances apoptosis induction by tyrosine kinase inhibitors in the eosinophilic leukemia-derived EoL-1 cell line

Carine Robert, A. Apáti, Christine Chomienne, Béla Papp

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Imatinib and retinoids induce apoptosis in FIP1L1/PDGFRα-positive EoL-1 leukemia cells. Although imatinib induces complete remission in most FIP1L1/PDGFRα-positive patients, response to imatinib is sometimes suboptimal. In order to enhance the potency of the molecularly targeted therapy of eosinophilic leukemia, we investigated the effect of retinoids combined with tyrosine kinase inhibitors on EoL-1 cells. We demonstrate that retinoids combined with tyrosine kinase inhibitors lead to enhanced apoptosis induction in EoL-1 cells. Our results suggest that tyrosine kinase inhibitors combined with retinoids may constitute a valuable therapeutic approach for sensitive neoplasias that may display enhanced anti-leukemic potency when compared to single drug treatments.

Original languageEnglish
Pages (from-to)343-346
Number of pages4
JournalLeukemia Research
Volume32
Issue number2
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Hypereosinophilic Syndrome
Retinoids
Tretinoin
Protein-Tyrosine Kinases
Apoptosis
Cell Line
Leukemia
Therapeutics
Pharmaceutical Preparations
Imatinib Mesylate
Neoplasms

Keywords

  • All-trans retinoic acid
  • Apoptosis
  • EoL-1
  • FIP1L1/PDGFRα
  • Imatinib
  • Retinoids
  • Tyrosine kinase inhibitors

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

All-trans-retinoic acid enhances apoptosis induction by tyrosine kinase inhibitors in the eosinophilic leukemia-derived EoL-1 cell line. / Robert, Carine; Apáti, A.; Chomienne, Christine; Papp, Béla.

In: Leukemia Research, Vol. 32, No. 2, 02.2008, p. 343-346.

Research output: Contribution to journalArticle

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