Alkaloids from Leucojum vernum and antiretroviral activity of amaryllidaceae alkaloids

László Szlávik, Ágnes Gyuris, J. Mináróvits, P. Forgó, J. Molnár, J. Hohmann

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Three alkaloids, lycorine, homolycorine and 2-O-acetyllycorine, were isolated from the bulbs of Leucojum vernum (Amaryllidaceae) and identified by means of NMR analysis. The alkaloids obtained from L. vernum and from other Amaryllidaceae species were studied in vitro for HIV-1 replication inhibitory activity on MT4 cells. The cytotoxicity of the compounds in uninfected cells was evaluated by using the MTT assay and the [3H]thymidine incorporation test. The antiviral activities were determined by means of the p24 antigen assay and solid-phase reverse transcriptase testing. The results demonstrate that trisphaeridine, lycorine, homolycorine, and haemanthamine possess high antiretroviral activities (IC50 = 0.4-7.3 μg/mL), accompanied by low therapeutic indices (Tl50 = 1.3-1.9).

Original languageEnglish
Pages (from-to)871-873
Number of pages3
JournalPlanta Medica
Volume70
Issue number9
DOIs
Publication statusPublished - Sep 2004

Fingerprint

Leucojum
Amaryllidaceae Alkaloids
lycorine
Amaryllidaceae
Alkaloids
alkaloids
Assays
RNA-directed DNA polymerase
RNA-Directed DNA Polymerase
assays
Cytotoxicity
thymidine
Human immunodeficiency virus 1
bulbs
Thymidine
Inhibitory Concentration 50
Antiviral Agents
inhibitory concentration 50
cytotoxicity
HIV-1

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Alkaloids from Leucojum vernum and antiretroviral activity of amaryllidaceae alkaloids. / Szlávik, László; Gyuris, Ágnes; Mináróvits, J.; Forgó, P.; Molnár, J.; Hohmann, J.

In: Planta Medica, Vol. 70, No. 9, 09.2004, p. 871-873.

Research output: Contribution to journalArticle

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AU - Forgó, P.

AU - Molnár, J.

AU - Hohmann, J.

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