Alkaloids derived from genus Veratrum and Peganum of Mongolian origin as multidrug resistance inhibitors of cancer cells

Antoaneta Ivanova, Julianna Serly, Veselin Christov, Bistra Stamboliyska, Joseph Molnar

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Alkaloids comprise one of the largest groups of plant secondary metabolites including vinca alkaloids. The ability of six alkaloids from Veratrum lobelianum, one from Veratrum nigrum and three from Peganum nigellastrum to modify transport activity of MDR1 was studied. Flow-cytometry in a multidrug-resistant human MDR1-gene-transfected mouse lymphoma cells (L5178Y) was applied. The inhibition of multidrug resistance was investigated by measuring the accumulation of rhodamine-123 in cancer cells. Veralosinine and veranigrine were the most effective resistance modifiers. In a checkerboard method veralosinine and veranigrine enhanced the antiproliferative effects of doxorubicin on MDR cells in combination. The structure-activity relationships were discussed.

Original languageEnglish
Pages (from-to)570-575
Number of pages6
JournalFitoterapia
Volume82
Issue number4
DOIs
Publication statusPublished - Jun 1 2011

Keywords

  • MDR1
  • Multidrug resistance
  • Peganum nigellastrum
  • Steroidal alkaloids
  • Veratrum lobelianum
  • Veratrum nigrum

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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