Alkaline phosphatase activity in human and rat liver tumors

I. Kovalszky, J. Kralovanszky, A. Jeney, K. Lapis, S. Karacsonyi, A. Szecheny

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Enzyme activity measurements of alkaline phosphatase in surgically removed human liver tumors showed elevated level of the enzyme in 6 focal nodular hyperplasias, reduction in 8 primary hepatocellular carcinomas, and no change in the 4 adenoma samples. The activity represented liver type of alkaline phosphatase nearly in all cases because it could be inhibited by L-homoarginine more extensively than by L-phenylalanine. Studies on polyacrylamide gel electrophoresis indicated the presence of a variant type isoenzyme only in one focal nodular hyperplasia and in two hepatocellular carcinomas, one of which showed a fibrolamellar structure whereas the other was associated to cirrhosis. The importance of the elevated amount of connective tissue in the tumor, resulting in an isoenzyme shift of alkaline phosphatase, received substantial support upon comparing chemically induced rat liver tumors with and without cirrhosis.

Original languageEnglish
Pages (from-to)144-148
Number of pages5
JournalOncology
Volume48
Issue number2
Publication statusPublished - 1991

Fingerprint

Human Activities
Focal Nodular Hyperplasia
Alkaline Phosphatase
Isoenzymes
Hepatocellular Carcinoma
Liver
Fibrosis
Homoarginine
Neoplasms
Enzymes
Phenylalanine
Adenoma
Connective Tissue
Polyacrylamide Gel Electrophoresis

Keywords

  • Alkaline phosphatase isoenzymes
  • Experimentally induced rat liver tumors
  • Human liver tumors
  • Variant type alkaline phosphatase

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kovalszky, I., Kralovanszky, J., Jeney, A., Lapis, K., Karacsonyi, S., & Szecheny, A. (1991). Alkaline phosphatase activity in human and rat liver tumors. Oncology, 48(2), 144-148.

Alkaline phosphatase activity in human and rat liver tumors. / Kovalszky, I.; Kralovanszky, J.; Jeney, A.; Lapis, K.; Karacsonyi, S.; Szecheny, A.

In: Oncology, Vol. 48, No. 2, 1991, p. 144-148.

Research output: Contribution to journalArticle

Kovalszky, I, Kralovanszky, J, Jeney, A, Lapis, K, Karacsonyi, S & Szecheny, A 1991, 'Alkaline phosphatase activity in human and rat liver tumors', Oncology, vol. 48, no. 2, pp. 144-148.
Kovalszky I, Kralovanszky J, Jeney A, Lapis K, Karacsonyi S, Szecheny A. Alkaline phosphatase activity in human and rat liver tumors. Oncology. 1991;48(2):144-148.
Kovalszky, I. ; Kralovanszky, J. ; Jeney, A. ; Lapis, K. ; Karacsonyi, S. ; Szecheny, A. / Alkaline phosphatase activity in human and rat liver tumors. In: Oncology. 1991 ; Vol. 48, No. 2. pp. 144-148.
@article{da46845ed0d4473a95783ef510692654,
title = "Alkaline phosphatase activity in human and rat liver tumors",
abstract = "Enzyme activity measurements of alkaline phosphatase in surgically removed human liver tumors showed elevated level of the enzyme in 6 focal nodular hyperplasias, reduction in 8 primary hepatocellular carcinomas, and no change in the 4 adenoma samples. The activity represented liver type of alkaline phosphatase nearly in all cases because it could be inhibited by L-homoarginine more extensively than by L-phenylalanine. Studies on polyacrylamide gel electrophoresis indicated the presence of a variant type isoenzyme only in one focal nodular hyperplasia and in two hepatocellular carcinomas, one of which showed a fibrolamellar structure whereas the other was associated to cirrhosis. The importance of the elevated amount of connective tissue in the tumor, resulting in an isoenzyme shift of alkaline phosphatase, received substantial support upon comparing chemically induced rat liver tumors with and without cirrhosis.",
keywords = "Alkaline phosphatase isoenzymes, Experimentally induced rat liver tumors, Human liver tumors, Variant type alkaline phosphatase",
author = "I. Kovalszky and J. Kralovanszky and A. Jeney and K. Lapis and S. Karacsonyi and A. Szecheny",
year = "1991",
language = "English",
volume = "48",
pages = "144--148",
journal = "Oncology",
issn = "0030-2414",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Alkaline phosphatase activity in human and rat liver tumors

AU - Kovalszky, I.

AU - Kralovanszky, J.

AU - Jeney, A.

AU - Lapis, K.

AU - Karacsonyi, S.

AU - Szecheny, A.

PY - 1991

Y1 - 1991

N2 - Enzyme activity measurements of alkaline phosphatase in surgically removed human liver tumors showed elevated level of the enzyme in 6 focal nodular hyperplasias, reduction in 8 primary hepatocellular carcinomas, and no change in the 4 adenoma samples. The activity represented liver type of alkaline phosphatase nearly in all cases because it could be inhibited by L-homoarginine more extensively than by L-phenylalanine. Studies on polyacrylamide gel electrophoresis indicated the presence of a variant type isoenzyme only in one focal nodular hyperplasia and in two hepatocellular carcinomas, one of which showed a fibrolamellar structure whereas the other was associated to cirrhosis. The importance of the elevated amount of connective tissue in the tumor, resulting in an isoenzyme shift of alkaline phosphatase, received substantial support upon comparing chemically induced rat liver tumors with and without cirrhosis.

AB - Enzyme activity measurements of alkaline phosphatase in surgically removed human liver tumors showed elevated level of the enzyme in 6 focal nodular hyperplasias, reduction in 8 primary hepatocellular carcinomas, and no change in the 4 adenoma samples. The activity represented liver type of alkaline phosphatase nearly in all cases because it could be inhibited by L-homoarginine more extensively than by L-phenylalanine. Studies on polyacrylamide gel electrophoresis indicated the presence of a variant type isoenzyme only in one focal nodular hyperplasia and in two hepatocellular carcinomas, one of which showed a fibrolamellar structure whereas the other was associated to cirrhosis. The importance of the elevated amount of connective tissue in the tumor, resulting in an isoenzyme shift of alkaline phosphatase, received substantial support upon comparing chemically induced rat liver tumors with and without cirrhosis.

KW - Alkaline phosphatase isoenzymes

KW - Experimentally induced rat liver tumors

KW - Human liver tumors

KW - Variant type alkaline phosphatase

UR - http://www.scopus.com/inward/record.url?scp=0025981940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025981940&partnerID=8YFLogxK

M3 - Article

C2 - 1847742

AN - SCOPUS:0025981940

VL - 48

SP - 144

EP - 148

JO - Oncology

JF - Oncology

SN - 0030-2414

IS - 2

ER -