Alkalimetria alkohol/víz elegyben potenciometriás végpontjelzéssel Kritikai észrevételek az Európai Gyógyszerkönyv új módszeréhez

Translated title of the contribution: Alkalimetry in alcohol/water mixture with potentiometric end-point detection. Critical remarks on a new method of the European Pharmacopoeia

Research output: Contribution to journalArticle

Abstract

The European Pharmacopoeia introduced a new alkalimetric method for assay of alkaloid (and other N-base) salts. The principle of method is: after preliminary addition of small amount of hydrochloric acid, titration is carried out with 0.1 N NaOH in alcohol/water mixture with potentiometric end-point detection. The applicability and reproducibility of this method have been examined at 11 substances. The results of alkalimetric method were compared to those obtained by nonaqueous titration (Ph. Hg. VII.). The method of Ph. Eur. i s well reproducible (SD < ± 0,50), however it could not be applied in case of some compounds (4 cases out of 11). Authors revealed that for the titration carried out according to the present prescription of Ph. Eur. 4., minimum pKa 7 should be the basicity of the alkaloids. They suggest to perform the titration in 70% alcohol and without preliminary addition of HCl for weaker bases.

Translated title of the contributionAlkalimetry in alcohol/water mixture with potentiometric end-point detection. Critical remarks on a new method of the European Pharmacopoeia
Original languageHungarian
Pages (from-to)179-183
Number of pages5
JournalActa pharmaceutica Hungarica
Volume73
Issue number3
Publication statusPublished - Oct 30 2003

ASJC Scopus subject areas

  • Pharmaceutical Science

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