Al(III)-binding ability of an octapeptide and its phosphorylated derivative

Dominik Hollender, Andrea Károly-Lakatos, Péter Forgó, Tamás Körtvélyesi, György Dombi, Zsuzsa Majer, Miklós Hollósi, Tamás Kiss, Akira Odani

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12 Citations (Scopus)


A synthetic octapeptide, H-GlyGluGlyGluGlySerGlyGly-OH, and its phosphorylated Ser derivative were synthetized and their solution speciation and binding modes in their complexes with Al(III) were measured. One goal of the work was find a lead compound for the design of a selective peptide-based Al(III) chelator. pH-potentiometry was used to characterize the stoichiometry and the stability of the species formed in the interactions of the metal ion and the peptides, while multinuclear NMR was applied to characterize the binding sites of the metal ion in the complexes. CD spectroscopy revealed a difference in the conformational behaviour of the phosphorylated peptide as compared with its non-phosphorylated parent derivative. The Al(III) is presumed to enhance aggregation through the -PO3H - Al3+-PO32 - Al3+- intermolecular bindings between the peptide chains. The results of molecular dynamics calculations supported the experimentally obtained secondary structures and the binding position of Al(III).

Original languageEnglish
Pages (from-to)351-361
Number of pages11
JournalJournal of Inorganic Biochemistry
Issue number3
Publication statusPublished - Mar 1 2006


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ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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