Aldosterone blocks the response to corticosterone in the raphe-hippocampal serotonin system

E. R. De Kloet, D. H.G. Versteeg, G. L. Kovacs

Research output: Contribution to journalArticle

99 Citations (Scopus)


The accumulation of serotonin induced by the monoamino oxidase inhibitor pargyline was used as an index for 5-HT turnover in the dorsal hippocampus and raphe area. A low dose of corticosterone administered s.c. immediately after adrenalectomy significantly increased serotonin turnover in both regions over the subsequent 1 h interval. The same dose of aldosterone was ineffective, but pretreatment with aldosterone blocked the serotonin response to corticosterone in the acutely adrenelectomized rat. [3H]Corticosterone administered to adrenalectomized rats was not retained by cell nuclei of the raphe area in a limited capacity manner as occurred in the hippocampus. Pretreatment with aldosterone blocked the uptake of [3H]corticosterone in hippocampal cell nuclei. It is concluded that corticosterone triggers a serotonin response and that the specificity of the corticosterone action suggests involvement of the steroid receptor system located postsynaptically to the raphe-hippocampal serotonin projection.

Original languageEnglish
Pages (from-to)323-327
Number of pages5
JournalBrain research
Issue number2
Publication statusPublished - Apr 4 1983


  • aldosterone
  • corticosterone
  • hippocampus
  • receptor
  • serotonin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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