The discovery of aldosterone as the principal mlneralocortlcoid hormone led to a new era in the study of the regulation and the pathological/clinical relevance of the fluid-salt homeostasis and blood pressure. Here, we discuss briefly the history of the discovery of aldosterone, its biosynthesis, the mechanism of action, regulation and the diseases which are associated with Its pathologically Increased production and hypertension: primary and secondary hyperaldosteronisms. Considering their clinical significance, we focus on primary hyperaldosteronisms as they represent a considerable portion of secondary hypertensions that can be definitively cured. Differential diagnosis Issues related to other forms of hypertension of different origins are discussed In detail. Recent findings of the past fifteen years Indicate that besides its classical genomical actions aldosterone has much more diverse non-genomlc actions as well Including proinflammatory and proflbrotic effects even In physiological concentrations. Based on these observations, aldosterone can be regarded as a risk hormone In the aetiology of cardiomyopathies, vasculopathies and neuropathies and therapeutical consequences are also discussed.
|Translated title of the contribution||Aldosterone at the beginning of the 21st century|
|Number of pages||12|
|Journal||Lege Artis Medicinae|
|Publication status||Published - Dec 1 2005|
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