Alcoholic liver disease and the gut-liver axis

Gyongyi Szabo, Shashi Bala

Research output: Contribution to journalReview article

221 Citations (Scopus)


Alcoholic liver disease (ALD) is one of the leading causes of liver diseases and liver-related death worldwide. Of the many factors that contribute to the pathogenesis of ALD, gut-derived lipopolysaccharide (LPS) plays a central role in induction of steatosis, inflammation, and fibrosis in the liver. In this review, we discuss the mechanisms by which alcohol contributes to increased gut permeability, the activation of Kupffer cells, and the inflammatory cascade by LPS. The role of the Toll-like receptor 4 (TLR4) complex in LPS recognition and the importance of the TLR4-induced signaling pathways are evaluated in ALD.

Original languageEnglish
Pages (from-to)1321-1329
Number of pages9
JournalWorld journal of gastroenterology
Issue number11
Publication statusPublished - Mar 21 2010


  • Endotoxin
  • Gut permeability
  • Kupffer cell
  • MicroRNA
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Gastroenterology

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