Alcoholic liver disease accelerates early hepatocellular cancer in amouse model

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

HCC is a rapidly increasing cancer worldwide. Most HCC rises in the setting of chronic and advanced liver disease caused by viral hepatitis, alcohol use, non-alcoholic liver disease or their combination. We found that in the mouse model, alcohol alone does not induce HCC, however, it can promote HCC development after a carcinogen exposure. Multiple mechanisms are involved in carcinogenesis and alcohol affects many of those including epithelial-mesenchymal transition, cancer stem marker expression and inflammation as evidenced in our HCC model.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages71-79
Number of pages9
DOIs
Publication statusPublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1032
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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Keywords

  • Alpha fetoprotein
  • Biliary cyst
  • DEN
  • Hypoxia-inducible factor-1alpha
  • Inflammation
  • Macrophage polarization
  • MiR-122
  • Neutrophil leukocyte
  • Stemness

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Szabó, G. (2018). Alcoholic liver disease accelerates early hepatocellular cancer in amouse model. In Advances in Experimental Medicine and Biology (pp. 71-79). (Advances in Experimental Medicine and Biology; Vol. 1032). Springer New York LLC. https://doi.org/10.1007/978-3-319-98788-0_5