Alcoholic liver disease accelerates early hepatocellular cancer in amouse model

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

HCC is a rapidly increasing cancer worldwide. Most HCC rises in the setting of chronic and advanced liver disease caused by viral hepatitis, alcohol use, non-alcoholic liver disease or their combination. We found that in the mouse model, alcohol alone does not induce HCC, however, it can promote HCC development after a carcinogen exposure. Multiple mechanisms are involved in carcinogenesis and alcohol affects many of those including epithelial-mesenchymal transition, cancer stem marker expression and inflammation as evidenced in our HCC model.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages71-79
Number of pages9
DOIs
Publication statusPublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1032
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Alcoholic Liver Diseases
Liver Neoplasms
Liver
Alcohols
Liver Diseases
Epithelial-Mesenchymal Transition
Carcinogens
Hepatitis
Neoplasms
Carcinogenesis
Inflammation

Keywords

  • Alpha fetoprotein
  • Biliary cyst
  • DEN
  • Hypoxia-inducible factor-1alpha
  • Inflammation
  • Macrophage polarization
  • MiR-122
  • Neutrophil leukocyte
  • Stemness

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Szabó, G. (2018). Alcoholic liver disease accelerates early hepatocellular cancer in amouse model. In Advances in Experimental Medicine and Biology (pp. 71-79). (Advances in Experimental Medicine and Biology; Vol. 1032). Springer New York LLC. https://doi.org/10.1007/978-3-319-98788-0_5

Alcoholic liver disease accelerates early hepatocellular cancer in amouse model. / Szabó, G.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 71-79 (Advances in Experimental Medicine and Biology; Vol. 1032).

Research output: Chapter in Book/Report/Conference proceedingChapter

Szabó, G 2018, Alcoholic liver disease accelerates early hepatocellular cancer in amouse model. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1032, Springer New York LLC, pp. 71-79. https://doi.org/10.1007/978-3-319-98788-0_5
Szabó G. Alcoholic liver disease accelerates early hepatocellular cancer in amouse model. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2018. p. 71-79. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-98788-0_5
Szabó, G. / Alcoholic liver disease accelerates early hepatocellular cancer in amouse model. Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. pp. 71-79 (Advances in Experimental Medicine and Biology).
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