Alcoholic liver disease

Helmut K. Seitz, Ramon Bataller, Helena Cortez-Pinto, Bin Gao, Antoni Gual, Carolin Lackner, Philippe Mathurin, Sebastian Mueller, G. Szabó, Hidekazu Tsukamoto

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide. ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is characterized by hepatic inflammation. Chronic ASH can eventually lead to fibrosis and cirrhosis and in some cases hepatocellular cancer (HCC). In addition, severe ASH (with or without cirrhosis) can lead to alcoholic hepatitis, which is an acute clinical presentation of ALD that is associated with liver failure and high mortality. Most individuals consuming >40 g of alcohol per day develop AFL; however, only a subset of individuals will develop more advanced disease. Genetic, epigenetic and non-genetic factors might explain the considerable interindividual variation in ALD phenotype. The pathogenesis of ALD includes hepatic steatosis, oxidative stress, acetaldehyde-mediated toxicity and cytokine and chemokine-induced inflammation. Diagnosis of ALD involves assessing patients for alcohol use disorder and signs of advanced liver disease. The degree of AFL and liver fibrosis can be determined by ultrasonography, transient elastography, MRI, measurement of serum biomarkers and liver biopsy histology. Alcohol abstinence achieved by psychosomatic intervention is the best treatment for all stages of ALD. In the case of advanced disease such as cirrhosis or HCC, liver transplantation may be required. Thus, new therapies are urgently needed.

Original languageEnglish
Article number16
JournalNature Reviews Disease Primers
Volume4
Issue number1
DOIs
Publication statusPublished - Dec 1 2018

Fingerprint

Alcoholic Fatty Liver
Alcoholic Liver Diseases
Fibrosis
Liver Neoplasms
Liver Diseases
Liver
Alcohols
Alcohol Abstinence
Alcoholic Hepatitis
Inflammation
Elasticity Imaging Techniques
Acetaldehyde
Liver Failure
Chemokines
Epigenomics
Liver Cirrhosis
Liver Transplantation
Ultrasonography
Histology
Oxidative Stress

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Seitz, H. K., Bataller, R., Cortez-Pinto, H., Gao, B., Gual, A., Lackner, C., ... Tsukamoto, H. (2018). Alcoholic liver disease. Nature Reviews Disease Primers, 4(1), [16]. https://doi.org/10.1038/s41572-018-0014-7

Alcoholic liver disease. / Seitz, Helmut K.; Bataller, Ramon; Cortez-Pinto, Helena; Gao, Bin; Gual, Antoni; Lackner, Carolin; Mathurin, Philippe; Mueller, Sebastian; Szabó, G.; Tsukamoto, Hidekazu.

In: Nature Reviews Disease Primers, Vol. 4, No. 1, 16, 01.12.2018.

Research output: Contribution to journalReview article

Seitz, HK, Bataller, R, Cortez-Pinto, H, Gao, B, Gual, A, Lackner, C, Mathurin, P, Mueller, S, Szabó, G & Tsukamoto, H 2018, 'Alcoholic liver disease', Nature Reviews Disease Primers, vol. 4, no. 1, 16. https://doi.org/10.1038/s41572-018-0014-7
Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C et al. Alcoholic liver disease. Nature Reviews Disease Primers. 2018 Dec 1;4(1). 16. https://doi.org/10.1038/s41572-018-0014-7
Seitz, Helmut K. ; Bataller, Ramon ; Cortez-Pinto, Helena ; Gao, Bin ; Gual, Antoni ; Lackner, Carolin ; Mathurin, Philippe ; Mueller, Sebastian ; Szabó, G. ; Tsukamoto, Hidekazu. / Alcoholic liver disease. In: Nature Reviews Disease Primers. 2018 ; Vol. 4, No. 1.
@article{bc3cec73deab4930b5cac7b2fa31d427,
title = "Alcoholic liver disease",
abstract = "Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide. ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is characterized by hepatic inflammation. Chronic ASH can eventually lead to fibrosis and cirrhosis and in some cases hepatocellular cancer (HCC). In addition, severe ASH (with or without cirrhosis) can lead to alcoholic hepatitis, which is an acute clinical presentation of ALD that is associated with liver failure and high mortality. Most individuals consuming >40 g of alcohol per day develop AFL; however, only a subset of individuals will develop more advanced disease. Genetic, epigenetic and non-genetic factors might explain the considerable interindividual variation in ALD phenotype. The pathogenesis of ALD includes hepatic steatosis, oxidative stress, acetaldehyde-mediated toxicity and cytokine and chemokine-induced inflammation. Diagnosis of ALD involves assessing patients for alcohol use disorder and signs of advanced liver disease. The degree of AFL and liver fibrosis can be determined by ultrasonography, transient elastography, MRI, measurement of serum biomarkers and liver biopsy histology. Alcohol abstinence achieved by psychosomatic intervention is the best treatment for all stages of ALD. In the case of advanced disease such as cirrhosis or HCC, liver transplantation may be required. Thus, new therapies are urgently needed.",
author = "Seitz, {Helmut K.} and Ramon Bataller and Helena Cortez-Pinto and Bin Gao and Antoni Gual and Carolin Lackner and Philippe Mathurin and Sebastian Mueller and G. Szab{\'o} and Hidekazu Tsukamoto",
year = "2018",
month = "12",
day = "1",
doi = "10.1038/s41572-018-0014-7",
language = "English",
volume = "4",
journal = "Nature Reviews Disease Primers",
issn = "2056-676X",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Alcoholic liver disease

AU - Seitz, Helmut K.

AU - Bataller, Ramon

AU - Cortez-Pinto, Helena

AU - Gao, Bin

AU - Gual, Antoni

AU - Lackner, Carolin

AU - Mathurin, Philippe

AU - Mueller, Sebastian

AU - Szabó, G.

AU - Tsukamoto, Hidekazu

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide. ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is characterized by hepatic inflammation. Chronic ASH can eventually lead to fibrosis and cirrhosis and in some cases hepatocellular cancer (HCC). In addition, severe ASH (with or without cirrhosis) can lead to alcoholic hepatitis, which is an acute clinical presentation of ALD that is associated with liver failure and high mortality. Most individuals consuming >40 g of alcohol per day develop AFL; however, only a subset of individuals will develop more advanced disease. Genetic, epigenetic and non-genetic factors might explain the considerable interindividual variation in ALD phenotype. The pathogenesis of ALD includes hepatic steatosis, oxidative stress, acetaldehyde-mediated toxicity and cytokine and chemokine-induced inflammation. Diagnosis of ALD involves assessing patients for alcohol use disorder and signs of advanced liver disease. The degree of AFL and liver fibrosis can be determined by ultrasonography, transient elastography, MRI, measurement of serum biomarkers and liver biopsy histology. Alcohol abstinence achieved by psychosomatic intervention is the best treatment for all stages of ALD. In the case of advanced disease such as cirrhosis or HCC, liver transplantation may be required. Thus, new therapies are urgently needed.

AB - Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide. ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is characterized by hepatic inflammation. Chronic ASH can eventually lead to fibrosis and cirrhosis and in some cases hepatocellular cancer (HCC). In addition, severe ASH (with or without cirrhosis) can lead to alcoholic hepatitis, which is an acute clinical presentation of ALD that is associated with liver failure and high mortality. Most individuals consuming >40 g of alcohol per day develop AFL; however, only a subset of individuals will develop more advanced disease. Genetic, epigenetic and non-genetic factors might explain the considerable interindividual variation in ALD phenotype. The pathogenesis of ALD includes hepatic steatosis, oxidative stress, acetaldehyde-mediated toxicity and cytokine and chemokine-induced inflammation. Diagnosis of ALD involves assessing patients for alcohol use disorder and signs of advanced liver disease. The degree of AFL and liver fibrosis can be determined by ultrasonography, transient elastography, MRI, measurement of serum biomarkers and liver biopsy histology. Alcohol abstinence achieved by psychosomatic intervention is the best treatment for all stages of ALD. In the case of advanced disease such as cirrhosis or HCC, liver transplantation may be required. Thus, new therapies are urgently needed.

UR - http://www.scopus.com/inward/record.url?scp=85051671112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051671112&partnerID=8YFLogxK

U2 - 10.1038/s41572-018-0014-7

DO - 10.1038/s41572-018-0014-7

M3 - Review article

AN - SCOPUS:85051671112

VL - 4

JO - Nature Reviews Disease Primers

JF - Nature Reviews Disease Primers

SN - 2056-676X

IS - 1

M1 - 16

ER -