Alcoholic hepatitis and HCV interactions in the modulation of liver disease

C. S. Punzalan, T. N. Bukong, Gyongyi Szabo

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Most HCV-infected patients regularly consume alcohol. Alcoholic liver disease (ALD) and chronic hepatitis C virus (HCV) infection together are the most common causes of liver disease worldwide. Although both factors independently cause liver disease, they synergistically promote rapid liver disease progression with devastating outcomes for patients. This review focuses on the prevalence, clinical characteristics and molecular pathophysiologic mechanisms of HCV infection associated with alcohol abuse. Recent findings have centred on the synergistic effect of alcohol and HCV on viral replication, hepatocyte apoptosis, oxidative stress, alcohol-induced 'leaky gut', miR-122 and immune dysregulation. Clinical and basic research findings presented here summarize key scientific findings with the aim of highlighting potential areas for new therapies and identifying ways of optimizing current treatments for alcoholics with HCV infection.

Original languageEnglish
Pages (from-to)769-776
Number of pages8
JournalJournal of Viral Hepatitis
Volume22
Issue number10
DOIs
Publication statusPublished - Oct 1 2015

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Alcoholic Hepatitis
Hepacivirus
Liver Diseases
Virus Diseases
Alcohols
Alcoholic Liver Diseases
Chronic Hepatitis C
Alcoholism
Disease Progression
Hepatocytes
Oxidative Stress
Apoptosis
Therapeutics
Research

Keywords

  • acute on chronic liver injury
  • fibrosis
  • inflammation
  • miR-122

ASJC Scopus subject areas

  • Hepatology
  • Virology
  • Infectious Diseases

Cite this

Alcoholic hepatitis and HCV interactions in the modulation of liver disease. / Punzalan, C. S.; Bukong, T. N.; Szabo, Gyongyi.

In: Journal of Viral Hepatitis, Vol. 22, No. 10, 01.10.2015, p. 769-776.

Research output: Contribution to journalReview article

Punzalan, C. S. ; Bukong, T. N. ; Szabo, Gyongyi. / Alcoholic hepatitis and HCV interactions in the modulation of liver disease. In: Journal of Viral Hepatitis. 2015 ; Vol. 22, No. 10. pp. 769-776.
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