Alcohol, liver, systemic inflammation and skin: A focus on patients with psoriasis

A. Farkas, L. Kemény

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Emerging evidence suggests that excessive alcohol consumption is associated with psoriasis. In alcoholics, antipsoriatic treatments are less efficient, but more toxic and an additional challenge is poor therapeutic compliance. There is a correlation between excess alcohol intake and increased risk of infections, but on the other hand alcohol and its metabolites can trigger a persistent systemic inflammation, mediated by pro-inflammatory cytokines released from activated Kupffer cells in the liver and from monocytes in the circulation. Ethanol and its metabolites can also enhance lymphocyte and keratinocyte activation and proliferation and can increase the mRNA levels of genes characteristic for proliferating keratinocytes. In this review, we discuss the mechanisms by which alcohol contributes to psoriasis development focusing on liver, systemic inflammation and skin.

Original languageEnglish
Pages (from-to)119-126
Number of pages8
JournalSkin Pharmacology and Physiology
Volume26
Issue number3
DOIs
Publication statusPublished - Jun 1 2013

Keywords

  • Acetaldehyde
  • Acetone
  • Alcohol
  • Alcoholic liver disease
  • Psoriasis
  • Systemic inflammation

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Dermatology

Fingerprint Dive into the research topics of 'Alcohol, liver, systemic inflammation and skin: A focus on patients with psoriasis'. Together they form a unique fingerprint.

  • Cite this