Alcohol-induced chronic pancreatitis in rats after temporary occlusion of biliopancreatic ducts with ethibloc

A. Pap, Laszlo Boros

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Chronic obstructive pancreatitis-like histological and biochemical alterations were provoked in male Wistar rats with Ethibloc occlusion of the common bile duct and the main pancreatic ducts. After the disappearance of the glue from the ducts, a gradual and almost total recovery was demonstrated during a 2-month observation period. About 12 g/kg of alcohol (20% vol/vol) given daily by gastric intubation and ad libitum intake inhibited the recovery of pancreatic weight and enzyme contents in the occluded rats, and within a 2-month period chronic calcifying-type pancreatitis became evident with some signs of remaining obstructive pancreatitis-like lesions. Cessation of alcohol administration after 2 months resulted in a recovery of pancreatic weight and enzyme contents, although morphological regeneration was less pronounced and calcification remained visible in some rats. A 50% raw soy flour diet provoked some further changes in the proportion of enzymes without any supplementary increases of pancreatic weight and protein content. This animal model of chronic pancreatitis demonstrates that chronic obstructive and cal-cifying pancreatitis can appear together and earlier if the etiological factors act in combination. Suppression of pancreatic regeneration by alcohol seems to be necessary to maintain chronic pancreatitis-like lesions and to develop calcification.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalPancreas.
Volume4
Issue number2
Publication statusPublished - 1989

Fingerprint

Chronic Pancreatitis
Alcohols
Weights and Measures
Pancreatitis
Regeneration
Enzymes
Pancreatic Ducts
Common Bile Duct
Flour
Intubation
Adhesives
Wistar Rats
Stomach
Animal Models
Observation
Diet
alcoholic prolamine solution
Proteins

Keywords

  • Alcohol
  • Calcification
  • Pancreatitis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Internal Medicine
  • Gastroenterology

Cite this

Alcohol-induced chronic pancreatitis in rats after temporary occlusion of biliopancreatic ducts with ethibloc. / Pap, A.; Boros, Laszlo.

In: Pancreas., Vol. 4, No. 2, 1989, p. 249-255.

Research output: Contribution to journalArticle

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