Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: Pooled analysis in the international head and neck cancer epidemiology consortium

Mia Hashibe, Paul Brennan, Simone Benhamou, Xavier Castellsague, Chu Chen, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Eleonora Fabianova, Victor Wünsch-Filho, Silvia Franceschi, Richard B. Hayes, Rolando Herrero, Sergio Koifman, Carlo La Vecchia, Philip Lazarus, Fabio Levi, Dana Mates, Elena Matos, Ana MenezesJoshua Muscat, Jose Eluf-Neto, Andrew F. Olshan, P. Rudnai, Stephen M. Schwartz, Elaine Smith, Erich M. Sturgis, Neonilia Szeszenia-Dabrowska, Renato Talamini, Qingyi Wei, Deborah M. Winn, David Zaridze, Witold Zatonski, Zuo Feng Zhang, Julien Berthiller, Paolo Boffetta

Research output: Contribution to journalArticle

560 Citations (Scopus)

Abstract

Background: At least 75% of head and neck cancers are attributable to a combination of cigarette smoking and alcohol drinking. A precise understanding of the independent association of each of these factors in the absence of the other with the risk of head and neck cancer is needed to elucidate mechanisms of head and neck carcinogenesis and to assess the efficacy of interventions aimed at controlling either risk factor. Methods: We examined the extent to which head and neck cancer is associated with cigarette smoking among never drinkers and with alcohol drinking among never users of tobacco. We pooled individual-level data from 15 case - control studies that included 10 244 head and neck cancer case subjects and 15 227 control subjects, of whom 1072 case subjects and 5775 control subjects were never users of tobacco and 1598 case subjects and 4051 control subjects were never drinkers of alcohol. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models. All statistical tests were two-sided. Results: Among never drinkers, cigarette smoking was associated with an increased risk of head and neck cancer (OR for ever versus never smoking = 2.13, 95% CI = 1.52 to 2.98), and there were clear dose - response relationships for the frequency, duration, and number of pack-years of cigarette smoking. Approximately 24% (95% CI = 16% to 31%) of head and neck cancer cases among nondrinkers in this study would have been prevented if these individuals had not smoked cigarettes. Among never users of tobacco, alcohol consumption was associated with an increased risk of head and neck cancer only when alcohol was consumed at high frequency (OR for three or more drinks per day versus never drinking = 2.04, 95% CI = 1.29 to 3.21). The association with high-frequency alcohol intake was limited to cancers of the oropharynx/hypopharynx and larynx. Conclusions: Our results represent the most precise estimates available of the independent association of each of the two main risk factors of head and neck cancer, and they exemplify the strengths of large-scale consortia in cancer epidemiology.

Original languageEnglish
Pages (from-to)777-789
Number of pages13
JournalJournal of the National Cancer Institute
Volume99
Issue number10
DOIs
Publication statusPublished - May 16 2007

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Head and Neck Neoplasms
Alcohol Drinking
Epidemiology
Smoking
Confidence Intervals
Odds Ratio
Alcohols
Tobacco
Logistic Models
Oropharyngeal Neoplasms
Hypopharynx
Laryngeal Neoplasms
Tobacco Use
Tobacco Products
Drinking
Case-Control Studies
Carcinogenesis
Neck
Head
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer : Pooled analysis in the international head and neck cancer epidemiology consortium. / Hashibe, Mia; Brennan, Paul; Benhamou, Simone; Castellsague, Xavier; Chen, Chu; Curado, Maria Paula; Maso, Luigino Dal; Daudt, Alexander W.; Fabianova, Eleonora; Wünsch-Filho, Victor; Franceschi, Silvia; Hayes, Richard B.; Herrero, Rolando; Koifman, Sergio; La Vecchia, Carlo; Lazarus, Philip; Levi, Fabio; Mates, Dana; Matos, Elena; Menezes, Ana; Muscat, Joshua; Eluf-Neto, Jose; Olshan, Andrew F.; Rudnai, P.; Schwartz, Stephen M.; Smith, Elaine; Sturgis, Erich M.; Szeszenia-Dabrowska, Neonilia; Talamini, Renato; Wei, Qingyi; Winn, Deborah M.; Zaridze, David; Zatonski, Witold; Zhang, Zuo Feng; Berthiller, Julien; Boffetta, Paolo.

In: Journal of the National Cancer Institute, Vol. 99, No. 10, 16.05.2007, p. 777-789.

Research output: Contribution to journalArticle

Hashibe, M, Brennan, P, Benhamou, S, Castellsague, X, Chen, C, Curado, MP, Maso, LD, Daudt, AW, Fabianova, E, Wünsch-Filho, V, Franceschi, S, Hayes, RB, Herrero, R, Koifman, S, La Vecchia, C, Lazarus, P, Levi, F, Mates, D, Matos, E, Menezes, A, Muscat, J, Eluf-Neto, J, Olshan, AF, Rudnai, P, Schwartz, SM, Smith, E, Sturgis, EM, Szeszenia-Dabrowska, N, Talamini, R, Wei, Q, Winn, DM, Zaridze, D, Zatonski, W, Zhang, ZF, Berthiller, J & Boffetta, P 2007, 'Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: Pooled analysis in the international head and neck cancer epidemiology consortium', Journal of the National Cancer Institute, vol. 99, no. 10, pp. 777-789. https://doi.org/10.1093/jnci/djk179
Hashibe, Mia ; Brennan, Paul ; Benhamou, Simone ; Castellsague, Xavier ; Chen, Chu ; Curado, Maria Paula ; Maso, Luigino Dal ; Daudt, Alexander W. ; Fabianova, Eleonora ; Wünsch-Filho, Victor ; Franceschi, Silvia ; Hayes, Richard B. ; Herrero, Rolando ; Koifman, Sergio ; La Vecchia, Carlo ; Lazarus, Philip ; Levi, Fabio ; Mates, Dana ; Matos, Elena ; Menezes, Ana ; Muscat, Joshua ; Eluf-Neto, Jose ; Olshan, Andrew F. ; Rudnai, P. ; Schwartz, Stephen M. ; Smith, Elaine ; Sturgis, Erich M. ; Szeszenia-Dabrowska, Neonilia ; Talamini, Renato ; Wei, Qingyi ; Winn, Deborah M. ; Zaridze, David ; Zatonski, Witold ; Zhang, Zuo Feng ; Berthiller, Julien ; Boffetta, Paolo. / Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer : Pooled analysis in the international head and neck cancer epidemiology consortium. In: Journal of the National Cancer Institute. 2007 ; Vol. 99, No. 10. pp. 777-789.
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title = "Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: Pooled analysis in the international head and neck cancer epidemiology consortium",
abstract = "Background: At least 75{\%} of head and neck cancers are attributable to a combination of cigarette smoking and alcohol drinking. A precise understanding of the independent association of each of these factors in the absence of the other with the risk of head and neck cancer is needed to elucidate mechanisms of head and neck carcinogenesis and to assess the efficacy of interventions aimed at controlling either risk factor. Methods: We examined the extent to which head and neck cancer is associated with cigarette smoking among never drinkers and with alcohol drinking among never users of tobacco. We pooled individual-level data from 15 case - control studies that included 10 244 head and neck cancer case subjects and 15 227 control subjects, of whom 1072 case subjects and 5775 control subjects were never users of tobacco and 1598 case subjects and 4051 control subjects were never drinkers of alcohol. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) were estimated using unconditional logistic regression models. All statistical tests were two-sided. Results: Among never drinkers, cigarette smoking was associated with an increased risk of head and neck cancer (OR for ever versus never smoking = 2.13, 95{\%} CI = 1.52 to 2.98), and there were clear dose - response relationships for the frequency, duration, and number of pack-years of cigarette smoking. Approximately 24{\%} (95{\%} CI = 16{\%} to 31{\%}) of head and neck cancer cases among nondrinkers in this study would have been prevented if these individuals had not smoked cigarettes. Among never users of tobacco, alcohol consumption was associated with an increased risk of head and neck cancer only when alcohol was consumed at high frequency (OR for three or more drinks per day versus never drinking = 2.04, 95{\%} CI = 1.29 to 3.21). The association with high-frequency alcohol intake was limited to cancers of the oropharynx/hypopharynx and larynx. Conclusions: Our results represent the most precise estimates available of the independent association of each of the two main risk factors of head and neck cancer, and they exemplify the strengths of large-scale consortia in cancer epidemiology.",
author = "Mia Hashibe and Paul Brennan and Simone Benhamou and Xavier Castellsague and Chu Chen and Curado, {Maria Paula} and Maso, {Luigino Dal} and Daudt, {Alexander W.} and Eleonora Fabianova and Victor W{\"u}nsch-Filho and Silvia Franceschi and Hayes, {Richard B.} and Rolando Herrero and Sergio Koifman and {La Vecchia}, Carlo and Philip Lazarus and Fabio Levi and Dana Mates and Elena Matos and Ana Menezes and Joshua Muscat and Jose Eluf-Neto and Olshan, {Andrew F.} and P. Rudnai and Schwartz, {Stephen M.} and Elaine Smith and Sturgis, {Erich M.} and Neonilia Szeszenia-Dabrowska and Renato Talamini and Qingyi Wei and Winn, {Deborah M.} and David Zaridze and Witold Zatonski and Zhang, {Zuo Feng} and Julien Berthiller and Paolo Boffetta",
year = "2007",
month = "5",
day = "16",
doi = "10.1093/jnci/djk179",
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volume = "99",
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TY - JOUR

T1 - Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer

T2 - Pooled analysis in the international head and neck cancer epidemiology consortium

AU - Hashibe, Mia

AU - Brennan, Paul

AU - Benhamou, Simone

AU - Castellsague, Xavier

AU - Chen, Chu

AU - Curado, Maria Paula

AU - Maso, Luigino Dal

AU - Daudt, Alexander W.

AU - Fabianova, Eleonora

AU - Wünsch-Filho, Victor

AU - Franceschi, Silvia

AU - Hayes, Richard B.

AU - Herrero, Rolando

AU - Koifman, Sergio

AU - La Vecchia, Carlo

AU - Lazarus, Philip

AU - Levi, Fabio

AU - Mates, Dana

AU - Matos, Elena

AU - Menezes, Ana

AU - Muscat, Joshua

AU - Eluf-Neto, Jose

AU - Olshan, Andrew F.

AU - Rudnai, P.

AU - Schwartz, Stephen M.

AU - Smith, Elaine

AU - Sturgis, Erich M.

AU - Szeszenia-Dabrowska, Neonilia

AU - Talamini, Renato

AU - Wei, Qingyi

AU - Winn, Deborah M.

AU - Zaridze, David

AU - Zatonski, Witold

AU - Zhang, Zuo Feng

AU - Berthiller, Julien

AU - Boffetta, Paolo

PY - 2007/5/16

Y1 - 2007/5/16

N2 - Background: At least 75% of head and neck cancers are attributable to a combination of cigarette smoking and alcohol drinking. A precise understanding of the independent association of each of these factors in the absence of the other with the risk of head and neck cancer is needed to elucidate mechanisms of head and neck carcinogenesis and to assess the efficacy of interventions aimed at controlling either risk factor. Methods: We examined the extent to which head and neck cancer is associated with cigarette smoking among never drinkers and with alcohol drinking among never users of tobacco. We pooled individual-level data from 15 case - control studies that included 10 244 head and neck cancer case subjects and 15 227 control subjects, of whom 1072 case subjects and 5775 control subjects were never users of tobacco and 1598 case subjects and 4051 control subjects were never drinkers of alcohol. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models. All statistical tests were two-sided. Results: Among never drinkers, cigarette smoking was associated with an increased risk of head and neck cancer (OR for ever versus never smoking = 2.13, 95% CI = 1.52 to 2.98), and there were clear dose - response relationships for the frequency, duration, and number of pack-years of cigarette smoking. Approximately 24% (95% CI = 16% to 31%) of head and neck cancer cases among nondrinkers in this study would have been prevented if these individuals had not smoked cigarettes. Among never users of tobacco, alcohol consumption was associated with an increased risk of head and neck cancer only when alcohol was consumed at high frequency (OR for three or more drinks per day versus never drinking = 2.04, 95% CI = 1.29 to 3.21). The association with high-frequency alcohol intake was limited to cancers of the oropharynx/hypopharynx and larynx. Conclusions: Our results represent the most precise estimates available of the independent association of each of the two main risk factors of head and neck cancer, and they exemplify the strengths of large-scale consortia in cancer epidemiology.

AB - Background: At least 75% of head and neck cancers are attributable to a combination of cigarette smoking and alcohol drinking. A precise understanding of the independent association of each of these factors in the absence of the other with the risk of head and neck cancer is needed to elucidate mechanisms of head and neck carcinogenesis and to assess the efficacy of interventions aimed at controlling either risk factor. Methods: We examined the extent to which head and neck cancer is associated with cigarette smoking among never drinkers and with alcohol drinking among never users of tobacco. We pooled individual-level data from 15 case - control studies that included 10 244 head and neck cancer case subjects and 15 227 control subjects, of whom 1072 case subjects and 5775 control subjects were never users of tobacco and 1598 case subjects and 4051 control subjects were never drinkers of alcohol. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models. All statistical tests were two-sided. Results: Among never drinkers, cigarette smoking was associated with an increased risk of head and neck cancer (OR for ever versus never smoking = 2.13, 95% CI = 1.52 to 2.98), and there were clear dose - response relationships for the frequency, duration, and number of pack-years of cigarette smoking. Approximately 24% (95% CI = 16% to 31%) of head and neck cancer cases among nondrinkers in this study would have been prevented if these individuals had not smoked cigarettes. Among never users of tobacco, alcohol consumption was associated with an increased risk of head and neck cancer only when alcohol was consumed at high frequency (OR for three or more drinks per day versus never drinking = 2.04, 95% CI = 1.29 to 3.21). The association with high-frequency alcohol intake was limited to cancers of the oropharynx/hypopharynx and larynx. Conclusions: Our results represent the most precise estimates available of the independent association of each of the two main risk factors of head and neck cancer, and they exemplify the strengths of large-scale consortia in cancer epidemiology.

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U2 - 10.1093/jnci/djk179

DO - 10.1093/jnci/djk179

M3 - Article

C2 - 17505073

AN - SCOPUS:34447266437

VL - 99

SP - 777

EP - 789

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 10

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