Agyria-pachygyria: Cerebral perfusion studies by 99mTc-HMPAO

Abdul Rahim Al-Suhaili, László Sztriha, Vaclav Prais, Michael Nork

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cerebral perfusion was investigated in three patients with agyria-pachygyria by using 99mTc-HMPAO SPECT in order to study the distribution of blood flow. Diffuse cortical hypoperfusion was found in all three infants. The visual cortex was not identifiable in two of the cases. The basal ganglia and cerebellum were prominent by their normal high activity, while tracer uptake was very low in the thalamus. The possible role of improper development of interneuronal connections and abnormal vascular pattern in background of the perfusion defect is discussed.

Original languageEnglish
Pages (from-to)138-143
Number of pages6
JournalBrain and Development
Volume19
Issue number2
DOIs
Publication statusPublished - Mar 1 1997

Keywords

  • Agyria-pachygyria-band spectrum
  • Cerebral perfusion
  • Lissencephaly
  • SPECT

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

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