Agonists and antagonists of regulatory peptides as tools to study regulation of pancreatic exocrine secretion, cell proliferation and gene expression

B. Burghardt, K. Kisfalvi, G. Varga, M. Papp

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

For more than two decades, our research group has been studying the pancreatic actions of three groups of regulatory peptides: members of the cholecystokinin/gastrin family, bombesin-like peptides and somatostatin. Investigating these peptides, our work has focused on three particularly interesting aspects: peptidergic regulation of pancreatic enzyme secretion and growth in adult rats, peptidergic control of pancreatic enzyme secretion and growth during postnatal development in rats, and peptidergic regulation of proliferation and differential gene expression in pancreatic adenocarcinoma cells. Our data confirmed that the control of the exocrine function of the pancreas is complex, and that it involves peptides such as the cholecystokinin/gastrin-like peptides, bombesin-like peptides and somatostatin. In these investigations, it became evident that selective peptide receptor agonists, antagonists and monoclonal antibodies raised against peptides are useful tools to identify the role of these bioactive peptides in pancreatic exocrine secretion and cell proliferation.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalScandinavian Journal of Gastroenterology, Supplement
Volume33
Issue number228
Publication statusPublished - 1998

Fingerprint

Cell Proliferation
Gene Expression
Peptides
Bombesin
Cholecystokinin
Gastrins
Exocrine Pancreas
Peptide Receptors
Enzymes
Growth
Adenocarcinoma
Monoclonal Antibodies
Research
somatostatin-like peptides

Keywords

  • Antagonist
  • Bombesin
  • Cholecystokinin
  • Immunoeutralization
  • Pancreas
  • Regulation
  • S omatostatin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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