Aging of Penicillium chrysogenum cultures under carbon starvation: I: Morphological changes and secondary metabolite production

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Abstract

In aging carbon-depleted cultures of an industrial β-lactam-producing strain of Penicillium chrysogenum the fragmentation and autolysis of mycelia was coupled with high production of NH3 (71.6 mM) and oxalate (37.8 mM) and low production of β-lactam (0.24 mM). Round-ended hyphal fragments consisting of two cells were found to be the dominant surviving forms, and addition of an extra dose of glucose in the autolytic phase reversed the biomass degradation by reinitiating cell growth.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalBiotechnology and applied biochemistry
Volume25
Issue number1
DOIs
Publication statusPublished - Jan 1 1997

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Molecular Medicine
  • Biomedical Engineering
  • Applied Microbiology and Biotechnology
  • Drug Discovery
  • Process Chemistry and Technology

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