Aging and comorbidities in acute pancreatitis I

A meta-analysis and systematic review based on 194,702 patients

Katalin Márta, Alina Marilena Lazarescu, Nelli Farkas, Péter Mátrai, Irina Cazacu, Máté Ottóffy, Tamás Habon, Bálint Erőss, A. Vincze, Gábor Veres, L. Czakó, Patrícia Sarlós, Z. Rakonczay, P. Hegyi

Research output: Contribution to journalArticle

Abstract

Background: Acute pancreatitis (AP) is one of the most common cause of hospitalization among gastrointestinal diseases worldwide. Although most of the cases are mild, approximately 10-20% of patients develop a severe course of disease with higher mortality rate. Scoring systems consider age as a risk factor of mortality and severity (BISAP; >60 years, JPN>70 years, RANSON; >55 years, APACHE II >45 years). If there is a correlation between aging and the clinical features of AP, how does age influence mortality and severity? Aim: This study aimed to systematically review the effects of aging on AP. Methods: A comprehensive systematic literature search was conducted in the Embase, Cochrane, and Pubmed databases. A meta-analysis was performed using the preferred reporting items for systematic review and meta-analysis statement (PRISMA). A total of 1,100 articles were found. After removing duplicates and articles containing insufficient or irrelevant data, 33 publications involving 194,702 AP patients were analyzed. Seven age categories were determined and several mathematical models, including conventional mathematical methods (linear regression), meta-analyses (random effect model and heterogeneity tests), meta-regression, funnel plot and Egger's test for publication bias were performed. Quality assessment was conducted using the modified Newcastle-Ottawa scale. The meta-analysis was registered in the PROSPERO database (CRD42017079253). Results: Aging greatly influences the outcome of AP. There was a low severe AP incidence in patients under 30 (1.6%); however, the incidence of severe AP showed a continuous, linear increase between 20 and 70 (0.193%/year) of up to 9.6%. The mortality rate was 0.9% in patients under 20 and demonstrated a continuous linear elevation until 59, however from this age the mortality rate started elevating with 9 times higher rate until the age of 70. The mortality rate between 20 and 59 grew 0.086%/year and 0.765%/year between 59 and 70. Overall, patients above 70 had a 19 times higher mortality rate than patients under 20. The mortality rate rising with age was confirmed by meta-regression (coefficient: 0.037 CI: 0.006-0.068, p = 0.022; adjusted r2: 13.8%), and severity also (coefficient: 0.035 CI: 0.019-0.052, p < 0.001; adjusted r2: 31.6%). Conclusion: Our analysis shows a likelihood of severe pancreatitis, as well as, pancreatitis-associated mortality is more common with advanced age. Importantly, the rapid elevation of mortality above the age of 59 suggests the involvement of additional deteriorating factors such as co-morbidity in elderly.

Original languageEnglish
Article number328
JournalFrontiers in Physiology
Volume10
Issue numberAPR
DOIs
Publication statusPublished - Jan 1 2019

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Pancreatitis
Meta-Analysis
Comorbidity
Mortality
Databases
Publication Bias
APACHE
Gastrointestinal Diseases
Incidence
PubMed
Publications
Linear Models
Hospitalization
Theoretical Models
Regression Analysis
Morbidity

Keywords

  • Acute pancreatitis
  • Aging
  • Co-morbidity
  • Mortality
  • Severity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Aging and comorbidities in acute pancreatitis I : A meta-analysis and systematic review based on 194,702 patients. / Márta, Katalin; Lazarescu, Alina Marilena; Farkas, Nelli; Mátrai, Péter; Cazacu, Irina; Ottóffy, Máté; Habon, Tamás; Erőss, Bálint; Vincze, A.; Veres, Gábor; Czakó, L.; Sarlós, Patrícia; Rakonczay, Z.; Hegyi, P.

In: Frontiers in Physiology, Vol. 10, No. APR, 328, 01.01.2019.

Research output: Contribution to journalArticle

Márta, K, Lazarescu, AM, Farkas, N, Mátrai, P, Cazacu, I, Ottóffy, M, Habon, T, Erőss, B, Vincze, A, Veres, G, Czakó, L, Sarlós, P, Rakonczay, Z & Hegyi, P 2019, 'Aging and comorbidities in acute pancreatitis I: A meta-analysis and systematic review based on 194,702 patients', Frontiers in Physiology, vol. 10, no. APR, 328. https://doi.org/10.3389/fphys.2019.00328
Márta, Katalin ; Lazarescu, Alina Marilena ; Farkas, Nelli ; Mátrai, Péter ; Cazacu, Irina ; Ottóffy, Máté ; Habon, Tamás ; Erőss, Bálint ; Vincze, A. ; Veres, Gábor ; Czakó, L. ; Sarlós, Patrícia ; Rakonczay, Z. ; Hegyi, P. / Aging and comorbidities in acute pancreatitis I : A meta-analysis and systematic review based on 194,702 patients. In: Frontiers in Physiology. 2019 ; Vol. 10, No. APR.
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T1 - Aging and comorbidities in acute pancreatitis I

T2 - A meta-analysis and systematic review based on 194,702 patients

AU - Márta, Katalin

AU - Lazarescu, Alina Marilena

AU - Farkas, Nelli

AU - Mátrai, Péter

AU - Cazacu, Irina

AU - Ottóffy, Máté

AU - Habon, Tamás

AU - Erőss, Bálint

AU - Vincze, A.

AU - Veres, Gábor

AU - Czakó, L.

AU - Sarlós, Patrícia

AU - Rakonczay, Z.

AU - Hegyi, P.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Acute pancreatitis (AP) is one of the most common cause of hospitalization among gastrointestinal diseases worldwide. Although most of the cases are mild, approximately 10-20% of patients develop a severe course of disease with higher mortality rate. Scoring systems consider age as a risk factor of mortality and severity (BISAP; >60 years, JPN>70 years, RANSON; >55 years, APACHE II >45 years). If there is a correlation between aging and the clinical features of AP, how does age influence mortality and severity? Aim: This study aimed to systematically review the effects of aging on AP. Methods: A comprehensive systematic literature search was conducted in the Embase, Cochrane, and Pubmed databases. A meta-analysis was performed using the preferred reporting items for systematic review and meta-analysis statement (PRISMA). A total of 1,100 articles were found. After removing duplicates and articles containing insufficient or irrelevant data, 33 publications involving 194,702 AP patients were analyzed. Seven age categories were determined and several mathematical models, including conventional mathematical methods (linear regression), meta-analyses (random effect model and heterogeneity tests), meta-regression, funnel plot and Egger's test for publication bias were performed. Quality assessment was conducted using the modified Newcastle-Ottawa scale. The meta-analysis was registered in the PROSPERO database (CRD42017079253). Results: Aging greatly influences the outcome of AP. There was a low severe AP incidence in patients under 30 (1.6%); however, the incidence of severe AP showed a continuous, linear increase between 20 and 70 (0.193%/year) of up to 9.6%. The mortality rate was 0.9% in patients under 20 and demonstrated a continuous linear elevation until 59, however from this age the mortality rate started elevating with 9 times higher rate until the age of 70. The mortality rate between 20 and 59 grew 0.086%/year and 0.765%/year between 59 and 70. Overall, patients above 70 had a 19 times higher mortality rate than patients under 20. The mortality rate rising with age was confirmed by meta-regression (coefficient: 0.037 CI: 0.006-0.068, p = 0.022; adjusted r2: 13.8%), and severity also (coefficient: 0.035 CI: 0.019-0.052, p < 0.001; adjusted r2: 31.6%). Conclusion: Our analysis shows a likelihood of severe pancreatitis, as well as, pancreatitis-associated mortality is more common with advanced age. Importantly, the rapid elevation of mortality above the age of 59 suggests the involvement of additional deteriorating factors such as co-morbidity in elderly.

AB - Background: Acute pancreatitis (AP) is one of the most common cause of hospitalization among gastrointestinal diseases worldwide. Although most of the cases are mild, approximately 10-20% of patients develop a severe course of disease with higher mortality rate. Scoring systems consider age as a risk factor of mortality and severity (BISAP; >60 years, JPN>70 years, RANSON; >55 years, APACHE II >45 years). If there is a correlation between aging and the clinical features of AP, how does age influence mortality and severity? Aim: This study aimed to systematically review the effects of aging on AP. Methods: A comprehensive systematic literature search was conducted in the Embase, Cochrane, and Pubmed databases. A meta-analysis was performed using the preferred reporting items for systematic review and meta-analysis statement (PRISMA). A total of 1,100 articles were found. After removing duplicates and articles containing insufficient or irrelevant data, 33 publications involving 194,702 AP patients were analyzed. Seven age categories were determined and several mathematical models, including conventional mathematical methods (linear regression), meta-analyses (random effect model and heterogeneity tests), meta-regression, funnel plot and Egger's test for publication bias were performed. Quality assessment was conducted using the modified Newcastle-Ottawa scale. The meta-analysis was registered in the PROSPERO database (CRD42017079253). Results: Aging greatly influences the outcome of AP. There was a low severe AP incidence in patients under 30 (1.6%); however, the incidence of severe AP showed a continuous, linear increase between 20 and 70 (0.193%/year) of up to 9.6%. The mortality rate was 0.9% in patients under 20 and demonstrated a continuous linear elevation until 59, however from this age the mortality rate started elevating with 9 times higher rate until the age of 70. The mortality rate between 20 and 59 grew 0.086%/year and 0.765%/year between 59 and 70. Overall, patients above 70 had a 19 times higher mortality rate than patients under 20. The mortality rate rising with age was confirmed by meta-regression (coefficient: 0.037 CI: 0.006-0.068, p = 0.022; adjusted r2: 13.8%), and severity also (coefficient: 0.035 CI: 0.019-0.052, p < 0.001; adjusted r2: 31.6%). Conclusion: Our analysis shows a likelihood of severe pancreatitis, as well as, pancreatitis-associated mortality is more common with advanced age. Importantly, the rapid elevation of mortality above the age of 59 suggests the involvement of additional deteriorating factors such as co-morbidity in elderly.

KW - Acute pancreatitis

KW - Aging

KW - Co-morbidity

KW - Mortality

KW - Severity

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