Aggressive infantile myofibromatosis: Report of a case of a clinically progressive congenital multiple fibromatosis

P. Molnár, E. Oláh, T. L. Miko, S. Gomba

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We report a case of congenital multiple fibromatosis (infantile myofibromatosis) showing the typical spindle-cellular proliferation with prominent vascularity on light microscopical observations. Electron microscopy showed the abundance of fibroblasts with conspicuous collagen and reticulin fibers together with numerous cells sharing the characteristics of both fibroblasts and smooth muscle cells (myofibroblasts). Neither visceral involvement nor ossification has been detected during the 4-year-long follow-up period. However, the clinical course has shown a slow, continuous, protracted though destructive proliferation of subcutaneous myofibroblastic nodules. These findings are contrasted with previous reports that claimed that the presence of myofibroblasts indicates benign behavior and results in the regression of fibromatous lesions.

Original languageEnglish
Pages (from-to)332-337
Number of pages6
JournalMedical and Pediatric Oncology
Volume14
Issue number6
Publication statusPublished - 1986

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Fibroma
Myofibroblasts
Fibroblasts
Reticulin
Osteogenesis
Smooth Muscle Myocytes
Electron Microscopy
Collagen
Cell Proliferation
Light
Congenital Generalized Fibromatosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Cite this

Aggressive infantile myofibromatosis : Report of a case of a clinically progressive congenital multiple fibromatosis. / Molnár, P.; Oláh, E.; Miko, T. L.; Gomba, S.

In: Medical and Pediatric Oncology, Vol. 14, No. 6, 1986, p. 332-337.

Research output: Contribution to journalArticle

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