Aggression and quantitative MRI measures of caudate in patients with chronic schizophrenia or schizoaffective disorder

Matthew J. Hoptman, Jan Volavka, Pál Czobor, Guido Gerig, Miranda Chakos, Joseph Blocher, Leslie L. Citrome, Brain Sheitman, Jean Pierre Lindenmayer, Jeffrey A. Lieberman, Robert M. Bilder

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33 Citations (Scopus)

Abstract

Caudate dysfunction is implicated in schizophrenia. However, little is known about the relationship between aggression and caudate volumes. Forty-nine patients received magnetic resonance imaging scanning in a double-blind treatment study in which aggression was measured. Caudate volumes were computed using a semiautomated method. The authors measured aggression with the Overt Aggression Scale and the Positive and Negative Syndrome Scale. Larger caudate volumes were associated with greater levels of aggression. The relationship between aggression and caudate volumes may be related to the iatrogenic effects of long-term treatment with typical antipsychotic agents or to a direct effect of schizophrenic processes on the caudate.

Original languageEnglish
Pages (from-to)509-515
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume18
Issue number4
DOIs
Publication statusPublished - Jan 1 2006

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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    Hoptman, M. J., Volavka, J., Czobor, P., Gerig, G., Chakos, M., Blocher, J., Citrome, L. L., Sheitman, B., Lindenmayer, J. P., Lieberman, J. A., & Bilder, R. M. (2006). Aggression and quantitative MRI measures of caudate in patients with chronic schizophrenia or schizoaffective disorder. Journal of Neuropsychiatry and Clinical Neurosciences, 18(4), 509-515. https://doi.org/10.1176/jnp.2006.18.4.509