Ageing population in the developed countries

some ethical consequences

M. Szente, C. Susanne

Research output: Contribution to journalArticle

Abstract

Dementia accompanies aging in certain susceptible individuals. The chemical function of the brain remains normal, but certain neurotransmitter-selective diseases, such as Parkinson's disease, Huntington's disease, and Alzheimer's disease occur more commonly with age. There are at least two issues troubling researchers of senile dementia at the moment. One is the contribution of cell death, as opposed to selective neuronal atrophy, to the pathology of degenerative disorders. The other is how early the onset of dementia might be detected. The resolution of such issues is important for the design of therapies for the common and most serious chronic, rather than acute, neurodegenerative disease. Alzheimer's disease is one of the most devastating neurological disorders. The ethical debate is often related to when human biological life ceases or when a person ceases to exist. If the elder is still a person, he/she is no more the same person. Huntington's disease is inherited as a highly penetrant, autosomal dominant neuronal disorder. A genetic test can accurately predict a person's risk and that of the children. As the knowledge of the genetic basis is increasing and prenatal diagnosis gets easier, the possibilities to avoid child disorders will become greater, but genetic testing raises problematic ethical issues. Ethical action involves the right to know and the right not to know, it involves freedom of choice and freedom implies knowledge. It is ethical that relatives in age of procreation should be informed. In any case, efficacy and safety of the procedure, the risk-benefit ratio for a particular disease must be judged to be acceptable and understood through informed consent by the patient or the family or both.

Original languageEnglish
Pages (from-to)89-98
Number of pages10
JournalGlobal Bioethics
Volume12
Issue number1-4
DOIs
Publication statusPublished - Jan 1 1999

Fingerprint

Developed Countries
dementia
Disease
Alzheimer Disease
Huntington Disease
Population
Dementia
human being
Genetic Testing
Acute Disease
Nervous System Diseases
Informed Consent
Prenatal Diagnosis
Ethics
Neurodegenerative Diseases
Atrophy
Neurotransmitter Agents
Parkinson Disease
decision making leeway
genetic test

Keywords

  • aging
  • dementia
  • genetic testing
  • mental diseases

ASJC Scopus subject areas

  • Philosophy
  • Health Policy
  • Health(social science)

Cite this

Ageing population in the developed countries : some ethical consequences. / Szente, M.; Susanne, C.

In: Global Bioethics, Vol. 12, No. 1-4, 01.01.1999, p. 89-98.

Research output: Contribution to journalArticle

@article{47892aaa019d4c98a6a3ae7fa86346af,
title = "Ageing population in the developed countries: some ethical consequences",
abstract = "Dementia accompanies aging in certain susceptible individuals. The chemical function of the brain remains normal, but certain neurotransmitter-selective diseases, such as Parkinson's disease, Huntington's disease, and Alzheimer's disease occur more commonly with age. There are at least two issues troubling researchers of senile dementia at the moment. One is the contribution of cell death, as opposed to selective neuronal atrophy, to the pathology of degenerative disorders. The other is how early the onset of dementia might be detected. The resolution of such issues is important for the design of therapies for the common and most serious chronic, rather than acute, neurodegenerative disease. Alzheimer's disease is one of the most devastating neurological disorders. The ethical debate is often related to when human biological life ceases or when a person ceases to exist. If the elder is still a person, he/she is no more the same person. Huntington's disease is inherited as a highly penetrant, autosomal dominant neuronal disorder. A genetic test can accurately predict a person's risk and that of the children. As the knowledge of the genetic basis is increasing and prenatal diagnosis gets easier, the possibilities to avoid child disorders will become greater, but genetic testing raises problematic ethical issues. Ethical action involves the right to know and the right not to know, it involves freedom of choice and freedom implies knowledge. It is ethical that relatives in age of procreation should be informed. In any case, efficacy and safety of the procedure, the risk-benefit ratio for a particular disease must be judged to be acceptable and understood through informed consent by the patient or the family or both.",
keywords = "aging, dementia, genetic testing, mental diseases",
author = "M. Szente and C. Susanne",
year = "1999",
month = "1",
day = "1",
doi = "10.1080/11287462.1999.10800749",
language = "English",
volume = "12",
pages = "89--98",
journal = "Global Bioethics",
issn = "1128-7462",
publisher = "Routledge",
number = "1-4",

}

TY - JOUR

T1 - Ageing population in the developed countries

T2 - some ethical consequences

AU - Szente, M.

AU - Susanne, C.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Dementia accompanies aging in certain susceptible individuals. The chemical function of the brain remains normal, but certain neurotransmitter-selective diseases, such as Parkinson's disease, Huntington's disease, and Alzheimer's disease occur more commonly with age. There are at least two issues troubling researchers of senile dementia at the moment. One is the contribution of cell death, as opposed to selective neuronal atrophy, to the pathology of degenerative disorders. The other is how early the onset of dementia might be detected. The resolution of such issues is important for the design of therapies for the common and most serious chronic, rather than acute, neurodegenerative disease. Alzheimer's disease is one of the most devastating neurological disorders. The ethical debate is often related to when human biological life ceases or when a person ceases to exist. If the elder is still a person, he/she is no more the same person. Huntington's disease is inherited as a highly penetrant, autosomal dominant neuronal disorder. A genetic test can accurately predict a person's risk and that of the children. As the knowledge of the genetic basis is increasing and prenatal diagnosis gets easier, the possibilities to avoid child disorders will become greater, but genetic testing raises problematic ethical issues. Ethical action involves the right to know and the right not to know, it involves freedom of choice and freedom implies knowledge. It is ethical that relatives in age of procreation should be informed. In any case, efficacy and safety of the procedure, the risk-benefit ratio for a particular disease must be judged to be acceptable and understood through informed consent by the patient or the family or both.

AB - Dementia accompanies aging in certain susceptible individuals. The chemical function of the brain remains normal, but certain neurotransmitter-selective diseases, such as Parkinson's disease, Huntington's disease, and Alzheimer's disease occur more commonly with age. There are at least two issues troubling researchers of senile dementia at the moment. One is the contribution of cell death, as opposed to selective neuronal atrophy, to the pathology of degenerative disorders. The other is how early the onset of dementia might be detected. The resolution of such issues is important for the design of therapies for the common and most serious chronic, rather than acute, neurodegenerative disease. Alzheimer's disease is one of the most devastating neurological disorders. The ethical debate is often related to when human biological life ceases or when a person ceases to exist. If the elder is still a person, he/she is no more the same person. Huntington's disease is inherited as a highly penetrant, autosomal dominant neuronal disorder. A genetic test can accurately predict a person's risk and that of the children. As the knowledge of the genetic basis is increasing and prenatal diagnosis gets easier, the possibilities to avoid child disorders will become greater, but genetic testing raises problematic ethical issues. Ethical action involves the right to know and the right not to know, it involves freedom of choice and freedom implies knowledge. It is ethical that relatives in age of procreation should be informed. In any case, efficacy and safety of the procedure, the risk-benefit ratio for a particular disease must be judged to be acceptable and understood through informed consent by the patient or the family or both.

KW - aging

KW - dementia

KW - genetic testing

KW - mental diseases

UR - http://www.scopus.com/inward/record.url?scp=85070446863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070446863&partnerID=8YFLogxK

U2 - 10.1080/11287462.1999.10800749

DO - 10.1080/11287462.1999.10800749

M3 - Article

VL - 12

SP - 89

EP - 98

JO - Global Bioethics

JF - Global Bioethics

SN - 1128-7462

IS - 1-4

ER -