Ageing as a price of cooperation and complexity: Self-organization of complex systems causes the gradual deterioration of constituent networks

Huba J M Kiss, Ágoston Mihalik, Tibor Nánási, Bálint Ory, Zoltán Spiró, Csaba Soti, Peter Csermely

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The network concept is increasingly used for the description of complex systems. Here, we summarize key aspects of the evolvability and robustness of the hierarchical network set of macromolecules, cells, organisms and ecosystems. Listing the costs and benefits of cooperation as a necessary behaviour to build this network hierarchy, we outline the major hypothesis of the paper: the emergence of hierarchical complexity needs cooperation, leading to the ageing (i.e. gradual deterioration) of the constituent networks. A stable environment develops cooperation, leading to over-optimization, and formation of an 'always-old' network, which accumulates damage, and dies in an apoptosis-like process. A rapidly changing environment develops competition, forming a 'forever-young' network, which may suffer an occasional over-perturbation, exhausting system resources, and causing death in a necrosis-like process. Giving a number of examples, we demonstrate how cooperation evokes the gradual accumulation of damage typical of ageing. Finally, we show how various forms of cooperation and consequent ageing emerge as key elements in all major steps of evolution, from the formation of protocells to the establishment of the globalized, modern human society.

Original languageEnglish
Pages (from-to)651-664
Number of pages14
JournalBioEssays
Volume31
Issue number6
DOIs
Publication statusPublished - 2009

Fingerprint

Deterioration
Large scale systems
Aging of materials
Artificial Cells
Cost-Benefit Analysis
Ecosystem
Necrosis
Apoptosis
Macromolecules
Ecosystems
Costs

Keywords

  • Ageing
  • Complexity
  • Cooperation
  • Evolution
  • Networks

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Ageing as a price of cooperation and complexity : Self-organization of complex systems causes the gradual deterioration of constituent networks. / Kiss, Huba J M; Mihalik, Ágoston; Nánási, Tibor; Ory, Bálint; Spiró, Zoltán; Soti, Csaba; Csermely, Peter.

In: BioEssays, Vol. 31, No. 6, 2009, p. 651-664.

Research output: Contribution to journalArticle

Kiss, Huba J M ; Mihalik, Ágoston ; Nánási, Tibor ; Ory, Bálint ; Spiró, Zoltán ; Soti, Csaba ; Csermely, Peter. / Ageing as a price of cooperation and complexity : Self-organization of complex systems causes the gradual deterioration of constituent networks. In: BioEssays. 2009 ; Vol. 31, No. 6. pp. 651-664.
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