Age related variations of some polymorphonuclear leukocyte functions

Tamás Fülöp, Gabriella Fóris, Imre Wórum, G. Paragh, András Leövey

Research output: Contribution to journalArticle

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Abstract

The age-related alterations of some biochemical processes in polymorphonuclear leukocytes (PMNL) obtained from 20 healthy aged male and 20 healthy aged female (age: 60-94 years) subjects were investigated. The basic level of luminol dependent chemiluminescence (LDCL) was increased, whereas the basal value of reduced/oxidized glutathione (GSH per GS-SG) was decreased in the aged groups. The enhancement of LDCL was more significant by PMNLs of aged males than of females. The change of both GSH and GS-SG levels during phagocytosis were diminished in the PMNLs of aged subjects. The l-alanine β-naphthylamide specific elastase like protease (ELP) activity measured in living cell suspension was markedly increased with aging in male subjects. Therefore, it was concluded that the aging of PMNLs is partly a sex related process. The intensive release of both β-glucuronidase (β-G) and ELP by the PMNLs of aged subjects after in vitro treatment with calcium ionophore A23187, Cytochalasin B or low density lipoprotein (LDL) suggests that they could play an important role in some aged-related disorders.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalMechanisms of Ageing and Development
Volume29
Issue number1
DOIs
Publication statusPublished - 1985

Fingerprint

Luminol
Chemiluminescence
Pancreatic Elastase
Neutrophils
Peptide Hydrolases
Aging of materials
Luminescence
Cytochalasin B
Glutathione Disulfide
Calcium Ionophores
Glucuronidase
Biochemical Phenomena
LDL Lipoproteins
Alanine
Suspensions
Cells
Calcimycin
Phagocytosis
Glutathione

Keywords

  • Aging
  • Glutathione
  • Intralysosomal enzymes
  • Polymorphonuclear leukocytes Chemiluminescence

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

Cite this

Age related variations of some polymorphonuclear leukocyte functions. / Fülöp, Tamás; Fóris, Gabriella; Wórum, Imre; Paragh, G.; Leövey, András.

In: Mechanisms of Ageing and Development, Vol. 29, No. 1, 1985, p. 1-8.

Research output: Contribution to journalArticle

Fülöp, Tamás ; Fóris, Gabriella ; Wórum, Imre ; Paragh, G. ; Leövey, András. / Age related variations of some polymorphonuclear leukocyte functions. In: Mechanisms of Ageing and Development. 1985 ; Vol. 29, No. 1. pp. 1-8.
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