Az öregedés mikroszko″pos és molekuláris jelei a vastagbélben, valamint ezek lehetséges szerepe az idoskori vastagbélrák kialakulásában

Translated title of the contribution: Age-related microscopic and molecular changes of the human colon, and their role in the development of colorectal cancer in elderly people

Katalin Leiszter, O. Galamb, F. Sípos, Kinga Toth, Gábor Valcz, Patai V. Árpád, Jeannette Molnár, B. Molnár, Z. Tulassay

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The gastrointestinal effect of aging, the recognition of its molecular background and the mapping its connections with several diseases like sporadic colorectal cancer of elder people are a new and promising area of molecular gastroenterology. Nowadays, it is a well-known fact that some age-related molecular changes (e.g.: DNA methylation, telomere shortening) can be detected in several types of colorectal cancers. The known epidemiologic and molecular biologic features of sporadic colorectal cancer are not enough to explain the genetic, gene expression or epigenetic changes that may be involved in the increase of the disease over 45-50 age years. The connections of these alterations to the process of aging are also unclear. The understanding and custom-tailored modification of these mechanisms are of great clinical importance regarding of prevention and modern therapeutic strategies. In this review, we aimed to summarize the age-related microscopic and molecular changes of the human colon, as well as their role in the development of colorectal cancer of the elder people.

Original languageHungarian
Pages (from-to)885-892
Number of pages8
JournalOrvosi Hetilap
Volume151
Issue number22
DOIs
Publication statusPublished - May 1 2010

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Colorectal Neoplasms
Colon
Telomere Shortening
Gastroenterology
DNA Methylation
Epigenomics
Gene Expression
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az öregedés mikroszko″pos és molekuláris jelei a vastagbélben, valamint ezek lehetséges szerepe az idoskori vastagbélrák kialakulásában. / Leiszter, Katalin; Galamb, O.; Sípos, F.; Toth, Kinga; Valcz, Gábor; V. Árpád, Patai; Molnár, Jeannette; Molnár, B.; Tulassay, Z.

In: Orvosi Hetilap, Vol. 151, No. 22, 01.05.2010, p. 885-892.

Research output: Contribution to journalArticle

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