Age-related loss of GABA-positive and GABA-negative neurons in neocortical transplants

A. Bragin, J. Takacs, J. Takács, J. Hámori, J. Hamori

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The numerical density of GABA immunopositive and GABA immunonegative neurons was quantitatively determined in 0, 12, 30 and 90 day-old neocortical transplants, derived from E17 rat embryos and transplanted into adult hosts. It was found that the original, very high neuronal density in the fetal transplant declined steadily after transplantation to the somatosensory cortex of adult rat. The decline in numerical density of GABA-positive neurons, however, was disproportionately larger than that of GABA-negative nerve cells: At 90 days the proportion of GABA-positive cells was 2.3% (in contrast to the 11.8% in the adult host cortex). The density of GABA-negative neurons, on the other hand, remained slightly higher than comparable values in the control cortex. The decline in density of GABA-positive neurons was continuous until the 90th post-transplantation day, while final, close to normal density values of GABA-negative nerve cells were already reached in 30 day-old grafts, with no significant change afterwards.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalJournal of Neural Transplantation and Plasticity
Volume4
Issue number1
DOIs
Publication statusPublished - 1993

Fingerprint

GABAergic Neurons
gamma-Aminobutyric Acid
Transplants
Transplantation
Neurons
Somatosensory Cortex
Reference Values
Embryonic Structures

Keywords

  • GABA-immunostaining
  • Neocortex
  • Numerical density
  • Transplantation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Age-related loss of GABA-positive and GABA-negative neurons in neocortical transplants. / Bragin, A.; Takacs, J.; Takács, J.; Hámori, J.; Hamori, J.

In: Journal of Neural Transplantation and Plasticity, Vol. 4, No. 1, 1993, p. 53-59.

Research output: Contribution to journalArticle

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