Age related impairment in phosphatidylinositol breakdown of polymorphonuclear granulocytes

T. Fülöp, Z. Varga, J. Csongor, G. Fóris, A. Leövey

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

It is well known that with aging the immune response decreases. Most of the effector functions occur through specific receptors. Thus, we investigated the effects of various stimulants, acting through receptors or directly through the GTP-binding Gi protein, on phosphatidylinositol breakdown in PMNLs of young and elderly subjects and try to modulate it. A marked decrease in inositol phosphate (IP1, IP2, IP3) formation in PMNLs of elderly was found under FMLP stimulation when compared to that of young subjects. Neither GTPγS, nor AIF-4 could induce an increase of IP3 in PMNLs of elderly comparable to that of young subjects. The results suggest that at least an alteration exists at the GTP-binding Gi protein level, as well as in the mechanism of linkage of the receptor to the G protein.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalFEBS Letters
Volume245
Issue number1-2
DOIs
Publication statusPublished - Mar 13 1989

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Phosphatidylinositols
Guanosine Triphosphate
GTP-Binding Proteins
Granulocytes
Inositol Phosphates
Aging of materials
Carrier Proteins

Keywords

  • (Granulocyte)
  • Aging
  • GTPγS
  • Inositol phosphate

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Age related impairment in phosphatidylinositol breakdown of polymorphonuclear granulocytes. / Fülöp, T.; Varga, Z.; Csongor, J.; Fóris, G.; Leövey, A.

In: FEBS Letters, Vol. 245, No. 1-2, 13.03.1989, p. 249-252.

Research output: Contribution to journalArticle

Fülöp, T. ; Varga, Z. ; Csongor, J. ; Fóris, G. ; Leövey, A. / Age related impairment in phosphatidylinositol breakdown of polymorphonuclear granulocytes. In: FEBS Letters. 1989 ; Vol. 245, No. 1-2. pp. 249-252.
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