Age-related changes of the representative modular structure in the brain

Bálint File, Zoltán Klimaj, Zoltán Somogyvári, Lajos R. Kozák, Gyula Gyebnár, Brigitta Tóth, Zsófia Kardos, I. Ulbert, M. Molnár

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

describing the changes of modularity in different clinical states can help to understand the alterations of the global processing mechanisms. In the current study we applied the modularity in a local scale. The method is based on measuring the decrease of the modularity caused by shifting a node from its own module to another module. On one hand local modularity measures the influence of a node in the formation of the modular organization. On the other hand we evaluated differences in the community membership of the nodes between the modular structures of two groups. The method was tested on resting-state fMRI data of 20 young and 20 elderly subjects. Increased local modularity of the occipital module was found in the young, which is in line with the previously reported increased segregation of the visual cortex in the young. Regions of the dorsal attention network were characterized with an increased local modularity in the elderly which suggest that these regions preserve the modular structure in advanced age. These findings indicate that applying the modularity on a local scale is a promising biomarker for detecting differences between age groups.

Original languageEnglish
Title of host publicationPRNI 2016 - 6th International Workshop on Pattern Recognition in Neuroimaging
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781467365307
DOIs
Publication statusPublished - Aug 24 2016
Event6th International Workshop on Pattern Recognition in Neuroimaging, PRNI 2016 - Trento, Italy
Duration: Jun 22 2016Jun 24 2016

Other

Other6th International Workshop on Pattern Recognition in Neuroimaging, PRNI 2016
CountryItaly
CityTrento
Period6/22/166/24/16

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Keywords

  • Aging
  • community detection
  • functional connectivity
  • modularity
  • representative network

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Electrical and Electronic Engineering
  • Biomedical Engineering

Cite this

File, B., Klimaj, Z., Somogyvári, Z., Kozák, L. R., Gyebnár, G., Tóth, B., Kardos, Z., Ulbert, I., & Molnár, M. (2016). Age-related changes of the representative modular structure in the brain. In PRNI 2016 - 6th International Workshop on Pattern Recognition in Neuroimaging [7552346] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/PRNI.2016.7552346