Age-related changes in electromechanical properties of canine ventricular muscle

effect of ouabain.

D. A. Lathrop, A. Varró, W. E. Gaum, S. Kaplan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this report, alterations between the electrical and mechanical responses of isolated neonatal and adult canine ventricular muscle preparations before and after ouabain exposure are described. No significant differences were observed between the two age groups in the concentration-dependent effects of ouabain on increasing contractile force or decreasing maximum diastolic transmembrane potential. The action potential plateau duration was decreased by high concentrations of ouabain (0.3-1 microM) in both neonatal and adult ventricular muscle. In addition, more adult preparations developed delayed afterdepolarizations associated with aftercontractions after exposure to ouabain than did neonatal preparations. These results suggest that the higher glycoside tolerance in neonatal dogs as compared with adults may be due in part to differences in the mechanisms responsible for development of abnormal ventricular automaticity. The results may also indicate that immature animals do not require higher glycoside levels to produce augmentation of cardiac contractility.

Original languageEnglish
Pages (from-to)681-687
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Volume14
Issue number5
Publication statusPublished - Nov 1989

Fingerprint

Ouabain
Canidae
Muscles
Glycosides
Membrane Potentials
Action Potentials
Age Groups
Dogs

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Age-related changes in electromechanical properties of canine ventricular muscle : effect of ouabain. / Lathrop, D. A.; Varró, A.; Gaum, W. E.; Kaplan, S.

In: Journal of Cardiovascular Pharmacology, Vol. 14, No. 5, 11.1989, p. 681-687.

Research output: Contribution to journalArticle

@article{c5fdc16da231459ab4ce37ece6109607,
title = "Age-related changes in electromechanical properties of canine ventricular muscle: effect of ouabain.",
abstract = "In this report, alterations between the electrical and mechanical responses of isolated neonatal and adult canine ventricular muscle preparations before and after ouabain exposure are described. No significant differences were observed between the two age groups in the concentration-dependent effects of ouabain on increasing contractile force or decreasing maximum diastolic transmembrane potential. The action potential plateau duration was decreased by high concentrations of ouabain (0.3-1 microM) in both neonatal and adult ventricular muscle. In addition, more adult preparations developed delayed afterdepolarizations associated with aftercontractions after exposure to ouabain than did neonatal preparations. These results suggest that the higher glycoside tolerance in neonatal dogs as compared with adults may be due in part to differences in the mechanisms responsible for development of abnormal ventricular automaticity. The results may also indicate that immature animals do not require higher glycoside levels to produce augmentation of cardiac contractility.",
author = "Lathrop, {D. A.} and A. Varr{\'o} and Gaum, {W. E.} and S. Kaplan",
year = "1989",
month = "11",
language = "English",
volume = "14",
pages = "681--687",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Age-related changes in electromechanical properties of canine ventricular muscle

T2 - effect of ouabain.

AU - Lathrop, D. A.

AU - Varró, A.

AU - Gaum, W. E.

AU - Kaplan, S.

PY - 1989/11

Y1 - 1989/11

N2 - In this report, alterations between the electrical and mechanical responses of isolated neonatal and adult canine ventricular muscle preparations before and after ouabain exposure are described. No significant differences were observed between the two age groups in the concentration-dependent effects of ouabain on increasing contractile force or decreasing maximum diastolic transmembrane potential. The action potential plateau duration was decreased by high concentrations of ouabain (0.3-1 microM) in both neonatal and adult ventricular muscle. In addition, more adult preparations developed delayed afterdepolarizations associated with aftercontractions after exposure to ouabain than did neonatal preparations. These results suggest that the higher glycoside tolerance in neonatal dogs as compared with adults may be due in part to differences in the mechanisms responsible for development of abnormal ventricular automaticity. The results may also indicate that immature animals do not require higher glycoside levels to produce augmentation of cardiac contractility.

AB - In this report, alterations between the electrical and mechanical responses of isolated neonatal and adult canine ventricular muscle preparations before and after ouabain exposure are described. No significant differences were observed between the two age groups in the concentration-dependent effects of ouabain on increasing contractile force or decreasing maximum diastolic transmembrane potential. The action potential plateau duration was decreased by high concentrations of ouabain (0.3-1 microM) in both neonatal and adult ventricular muscle. In addition, more adult preparations developed delayed afterdepolarizations associated with aftercontractions after exposure to ouabain than did neonatal preparations. These results suggest that the higher glycoside tolerance in neonatal dogs as compared with adults may be due in part to differences in the mechanisms responsible for development of abnormal ventricular automaticity. The results may also indicate that immature animals do not require higher glycoside levels to produce augmentation of cardiac contractility.

UR - http://www.scopus.com/inward/record.url?scp=0024763629&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024763629&partnerID=8YFLogxK

M3 - Article

VL - 14

SP - 681

EP - 687

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

IS - 5

ER -